PMID: 11325489Apr 28, 2001Paper

Docetaxel in combination with gemcitabine plus rhG-CSF support as second-line treatment in non-small cell lung cancer. A multicenter phase II study

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
S KakolyrisGreek Cooperative Group for Lung Cancer

Abstract

Docetaxel in combination with gemcitabine is an active front-line chemotherapy regimen against non-small cell lung cancer (NSCLC) with acceptable toxicity. A multicenter phase II study was conducted in order to determine the toxicity and efficacy of this combination, as salvage treatment in patients progressing after a cisplatin-based front line regimens. Thirty-two patients with histologically confirmed, bidimensionally measurable NSCLC, who failed prior cisplatin-based chemotherapy were enrolled. The patients' median age was 62.5 years, 29 (91%) were male, 23 (72%) had disease stage IV, and 22 (69%) had a performance status (WHO) 0-1. Gemcitabine (900 mg/m(2)) was administered on days 1 and 8 and docetaxel (100 mg/m(2)) on day 8, after appropriate premedication. rhG-CSF (150 microg/m(2)) was given prophylactically from day 9 to 15. Treatment was repeated on an outpatient basis every three weeks. A total of 127 chemotherapy cycles were administered. In an intention-to-treat analysis five patients (15.6%; 95% CI: 3.04-28.21%) achieved a partial response, 11 (34.4%) stable disease, and 16 (50%) progressive disease. The median duration of response was 9 months, the median TTP 7 months, and the overall median survival 6.5 months; ...Continue Reading

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Citations

Oct 18, 2003·Critical Reviews in Oncology/hematology·M PietropaoloL Repetto
Dec 7, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Vassilis A Georgoulias
Dec 25, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Roberto PetrioliGuido Francini
Apr 26, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Ornella BelvedereFrancesco Grossi
Jan 18, 2003·International Journal of Cancer. Journal International Du Cancer·Derrick S GrantAdam P Dicker
Jan 11, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Toni IbrahimDino Amadori
Dec 18, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Marcus A NeubauerUNKNOWN Members of the US Oncology Study Group
Jul 13, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Floris M WachtersHarry J M Groen
May 16, 2006·Critical Reviews in Oncology/hematology·Francesco Grossi, Marcello Tiseo
Dec 20, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Fabrice BarlésiJean-Louis Pujol
Dec 24, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David G PfisterUNKNOWN American Society of Clinical Oncology
Feb 6, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Manuel CoboManuel Benavides
Nov 1, 2001·The Cochrane Database of Systematic Reviews·X BonfillJ Montesinos
Jun 22, 2002·The Cochrane Database of Systematic Reviews·X BonfillJ Montesinos

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