Docetaxel in prostate cancer: a familiar face as the new standard in a hormone-sensitive setting

Therapeutic Advances in Medical Oncology
Javier PuenteJose Angel Arranz

Abstract

The increasing knowledge of prostate cancer is leading to many questions about its natural history and to reconsider conventional therapeutic strategies. Androgen ablation therapy has been the standard therapy in the advanced setting. Although docetaxel has demonstrated increased survival in patients with metastatic prostate cancer who had progressed to hormone treatments, due to its potential toxicity the role of chemotherapy has been relegated to patients who were symptomatic or who had high tumor burden. Several studies have assessed whether docetaxel could have a role in hormone-sensitive disease or even in earlier stages with no distant metastases. In the CHAARTED and STAMPEDE studies, docetaxel provides an unprecedented increase in overall survival (OS). This review summarizes the evidence behind the paradigm shift to strengthening docetaxel as a new standard of treatment that prolongs survival in earlier stages of prostate cancer.

References

Oct 8, 2004·The New England Journal of Medicine·Ian F TannockUNKNOWN TAX 327 Investigators
Jan 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dominik R BertholdIan F Tannock
Apr 20, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tanya B DorffL Michael Glode
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Jul 17, 2015·JAMA Oncology·UNKNOWN Global Burden of Disease Cancer CollaborationMohsen Naghavi
Jul 25, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C ParkerUNKNOWN ESMO Guidelines Committee
Aug 6, 2015·The New England Journal of Medicine·Christopher J SweeneyRobert S DiPaola
Mar 13, 2016·Current Urology Reports·Eugene J Pietzak, James A Eastham

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Citations

Aug 30, 2018·Current Drug Safety·M KanakisN Pharmakakis
Oct 11, 2019·Nutrients·Seungjin NohBonglee Kim
Jun 4, 2019·Therapeutic Advances in Medical Oncology·Sol-Bi ShinHyungshin Yim
Aug 29, 2018·Cancers·Prashanth K B NageshMurali M Yallapu
Aug 31, 2018·Case Reports in Hematology·Karan SeegobinLara Zuberi
Mar 29, 2018·Molecular Cancer Research : MCR·Avital LevWafik S El-Deiry
Dec 25, 2019·International Journal of Biological Macromolecules·Milad AshrafizadehVijay Kumar Thakur
May 23, 2021·Andrologia·Yun PengHaitao Wang
Jun 10, 2021·Cell Death & Disease·Lifeng DingGonghui Li
Sep 26, 2019·ACS Applied Materials & Interfaces·Prashanth K B NageshMurali M Yallapu

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Clinical Trials Mentioned

NCT00116142
NCT00376792
NCT00653848
NCT00528866
NCT00430183

Software Mentioned

CHAARTED
STAMPEDE

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