Abstract
Pre-treatment with high-dose 1alpha,25-dihydroxyvitamin D(3) (1,25-VD) enhanced the antitumor activity of docetaxel in the androgen-independent prostate cancer cell line, PC-3. The effect manifested as an increasing population of apoptotic cells and amount of pro-apoptotic protein, Bax, under combined treatment compared with single treatment of either 1,25-VD or docetaxel alone. We further demonstrated that pre-treatment with 1,25-VD reduced the expression of multidrug resistance-associated protein-1 at both the mRNA and protein levels. This suggests pre-treatment with 1,25-VD can potentiate cytotoxicity of docetaxel in PC-3 due to 1,25-VD reducing multidrug resistance-associated protein-1 expression.
References
Jan 1, 1993·The Prostate·A G CarrollE P Gelmann
Jan 7, 1998·The Journal of Cell Biology·K G WolterR J Youle
Dec 30, 1999·Endocrinology·S E BluttN L Weigel
Dec 23, 2000·The Journal of Urology·J P Van BrusselG H Mickisch
Apr 27, 2001·Biochemical and Biophysical Research Communications·H S KimC H Choi
Dec 19, 2002·Endocrinology·Tara C PolekNancy L Weigel
Dec 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tomasz M BeerW David Henner
Jun 26, 2003·Experimental Eye Research·Nicole WagnerHolger Scholz
Oct 8, 2003·The Oncologist·Gregory D LeonardSusan E Bates
Oct 25, 2003·Oncogene·Gary D Kruh, Martin G Belinsky
Mar 30, 2004·Oncogene·Bo-Ying BaoYi-Fen Lee
Oct 8, 2004·The New England Journal of Medicine·Ian F TannockUNKNOWN TAX 327 Investigators
Oct 8, 2004·The New England Journal of Medicine·Daniel P PetrylakE David Crawford
Citations
Sep 16, 2008·Molecular Cancer Therapeutics·Yingyu MaCandace S Johnson
Feb 23, 2008·Endocrine Reviews·Murielle MimeaultSurinder K Batra
May 28, 2013·International Journal of Oncology·Hisanori UeharaKeisuke Izumi
Jun 19, 2014·International Journal of Nanomedicine·Jae-Young LeeDae-Duk Kim
May 3, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Hitesh KulhariRamakrishna Sistla
Apr 10, 2015·Pharmaceutical Biology·Marco GiammancoGaetano Leto
Jul 15, 2016·PeerJ·Reem T AttiaAshraf B Abdel-Naim
Jul 31, 2013·Progress in Histochemistry and Cytochemistry·Isabelle ClinckspoorBrigitte Decallonne
Jan 27, 2017·Nutrients·Mohamed A Abu El Maaty, Stefan Wölfl
Nov 14, 2012·Urologia Internationalis·Ali ShamseddineMohammad A Bulbul
Sep 2, 2014·The Prostate·Steven KregelDonald J Vander Griend
May 7, 2016·Journal of Cellular Biochemistry·Eunsohl LeeRussell S Taichman
Sep 22, 2012·The Prostate·Chengfei LiuAllen C Gao
Feb 27, 2018·Cancer Control : Journal of the Moffitt Cancer Center·Kimberly L SantucciJohn G Baust
Nov 16, 2012·Natural Product Reports·Jorge A R SalvadorM Luisa Sá e Melo
May 13, 2014·Molecular Cancer Therapeutics·Sharanjot SainiGuoren Deng
Apr 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Steven AttiaGlenn Liu
Jan 26, 2021·The Journal of Steroid Biochemistry and Molecular Biology·Mohamed Ben-EltrikiEmma S Tomlinson Guns
Jan 23, 2021·Experimental and Molecular Pathology·Hakan SoyluIsmail Ustunel
Apr 15, 2015·Seminars in Cancer Biology·Lynnette R FergusonChristopher A Maxwell
Apr 29, 2008·Current Opinion in Endocrinology, Diabetes, and Obesity