Docetaxel-induced growth inhibition and apoptosis in androgen independent prostate cancer cells are enhanced by 1alpha,25-dihydroxyvitamin D3

Cancer Letters
Huei-Ju TingYi-Fen Lee

Abstract

Pre-treatment with high-dose 1alpha,25-dihydroxyvitamin D(3) (1,25-VD) enhanced the antitumor activity of docetaxel in the androgen-independent prostate cancer cell line, PC-3. The effect manifested as an increasing population of apoptotic cells and amount of pro-apoptotic protein, Bax, under combined treatment compared with single treatment of either 1,25-VD or docetaxel alone. We further demonstrated that pre-treatment with 1,25-VD reduced the expression of multidrug resistance-associated protein-1 at both the mRNA and protein levels. This suggests pre-treatment with 1,25-VD can potentiate cytotoxicity of docetaxel in PC-3 due to 1,25-VD reducing multidrug resistance-associated protein-1 expression.

References

Jan 1, 1993·The Prostate·A G CarrollE P Gelmann
Jan 7, 1998·The Journal of Cell Biology·K G WolterR J Youle
Dec 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tomasz M BeerW David Henner
Oct 8, 2003·The Oncologist·Gregory D LeonardSusan E Bates
Oct 25, 2003·Oncogene·Gary D Kruh, Martin G Belinsky
Oct 8, 2004·The New England Journal of Medicine·Ian F TannockUNKNOWN TAX 327 Investigators
Oct 8, 2004·The New England Journal of Medicine·Daniel P PetrylakE David Crawford

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Citations

Jun 19, 2014·International Journal of Nanomedicine·Jae-Young LeeDae-Duk Kim
Apr 10, 2015·Pharmaceutical Biology·Marco GiammancoGaetano Leto
Jul 31, 2013·Progress in Histochemistry and Cytochemistry·Isabelle ClinckspoorBrigitte Decallonne
Sep 22, 2012·The Prostate·Chengfei LiuAllen C Gao
Feb 27, 2018·Cancer Control : Journal of the Moffitt Cancer Center·Kimberly L SantucciJohn G Baust
Nov 16, 2012·Natural Product Reports·Jorge A R SalvadorM Luisa Sá e Melo
May 13, 2014·Molecular Cancer Therapeutics·Sharanjot SainiGuoren Deng
Apr 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Steven AttiaGlenn Liu
Jan 26, 2021·The Journal of Steroid Biochemistry and Molecular Biology·Mohamed Ben-EltrikiEmma S Tomlinson Guns
Apr 29, 2008·Current Opinion in Endocrinology, Diabetes, and Obesity

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