Docetaxel loaded oleic acid-coated hydroxyapatite nanoparticles enhance the docetaxel-induced apoptosis through activation of caspase-2 in androgen independent prostate cancer cells

Journal of Controlled Release : Official Journal of the Controlled Release Society
Yun LuoXin Gao

Abstract

Docetaxel (Dtxl) remains the preferred choice of improving the survival of patients with hormone refractory prostate cancer (HRPC), but many patients suffer from modest drug response and significant toxicity. In the present study, we investigated the efficiency of novel Dtxl loaded-[1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-carboxy(polyethylene glycol)]2000 (DSPE-PEG-COOH) stabilized-oleic acid (OA) coated hydroxyapatite (HA) nanoparticles (Dtxl-NPs) and gained insights into the molecular mechanism of the apoptosis induced by these novel Dtxl-loaded nanoparticles. The drug encapsulation efficiency of Dtxl was 83.6% and the sustained drug release was observed over 30days. The Dtxl-NPs exhibited significantly more cytotoxicity in both prostate cancer cell lines (PC3 and DU145) compared with Dtxl in vitro and increased the Dtxl-induced apoptosis in the PC3 cells. Cell cycle analysis showed that the PC3 cells treated with Dtxl-NPs exhibited significant arrest in the G2-M phase but a higher sub-G(0)/G(1) population when compared with Dtxl. The enhanced apoptosis induced by Dtxl-NPs in the PC3 cells was associated with the changes in mitochondrial membrane potential (MMP) and seemed to involve the activation of caspase-2. The...Continue Reading

References

Jan 7, 1998·The Journal of Cell Biology·K G WolterR J Youle
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·S K HobbsR K Jain
Feb 8, 2002·The Journal of Biological Chemistry·Yin GuoEmad S Alnemri
Sep 13, 2003·World Journal of Gastroenterology : WJG·Zhi-Su LiuZhong-Li Ai
Sep 19, 2003·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Jindrich Kopecek
Oct 31, 2003·Expert Reviews in Molecular Medicine·M Links, R Brown
Jan 17, 2004·Cancer Biology & Therapy·Avi S RetterWilliam L Dahut
May 5, 2004·Seminars in Oncology·Vasily J Assikis, Jonathan W Simons
Oct 8, 2004·The New England Journal of Medicine·Ian F TannockUNKNOWN TAX 327 Investigators
Oct 8, 2004·The New England Journal of Medicine·Daniel P PetrylakE David Crawford
Apr 19, 2005·Molecular Pharmaceutics·Jayanth Panyam, Vinod Labhasetwar
Feb 21, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xu Dong ZhangPeter Hersey
Feb 20, 2007·Molecular Cancer Therapeutics·Nizar M MhaidatPeter Hersey
Mar 30, 2007·Pharmaceutical Research·Lilian E van VlerkenMansoor M Amiji
Jun 7, 2007·Pharmaceutical Research·Birgit RombergGert Storm
Sep 25, 2007·Journal of Materials Science. Materials in Medicine·Jie HuangWilliam Bonfield
Feb 19, 2008·Expert Review of Anticancer Therapy·Ulka Vaishampayan, Maha Hussain
Jul 26, 2008·Nature Nanotechnology·Wen JiangWarren C W Chan
Dec 30, 2008·Biomaterials·Juliana M ChanOmid C Farokhzad
May 29, 2009·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun

❮ Previous
Next ❯

Citations

Apr 23, 2013·Asian Journal of Andrology·Shan-Cheng RenYing-Hao Sun
Nov 15, 2011·DNA and Cell Biology·Soo-Hyun Kim, Crispin R Dass
May 16, 2013·Cancer Cell International·Michael JelínekJan Kovář
Feb 6, 2014·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Ming-Ji JinZhong-Gao Gao
Jan 10, 2014·Journal of Materials Science. Materials in Medicine·Fei JiangXin Zhao
May 18, 2013·Advanced Drug Delivery Reviews·Koen RaemdonckStefaan C De Smedt
Mar 10, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Haibin LiDeping Wang
Jun 7, 2011·Bioorganic & Medicinal Chemistry·Changyan LiangXiaomao Li
Jun 22, 2015·Colloids and Surfaces. B, Biointerfaces·Shweta SharmaP R Mishra
Apr 21, 2012·ChemMedChem·Pengxiang Zhao, Didier Astruc
Apr 3, 2012·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Kate FoxNhiem Tran
Feb 26, 2011·Journal of Peptide Science : an Official Publication of the European Peptide Society·Neha ShahHarendra S Parekh
Jan 4, 2012·Journal of Biomedical Materials Research. Part a·Jing XuZhuo Yang
Oct 4, 2011·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Amra TabakovićJames H Adair
Mar 29, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Xiaowei HuangHesun Zhu
Aug 12, 2015·Chemical Reviews·Yulin LiHelena Tomás
Aug 21, 2014·International Journal of Pharmaceutics·Mei-Hua QuJian-Ting Long
Feb 17, 2015·Cancer Cell International·Michael JelínekJan Kovář
Apr 17, 2015·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Vivek Venkatramani
Jan 13, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Ana Karen Sánchez LafargaGregorio Guadalupe Carbajal Arízaga
Jan 12, 2019·Pharmaceutical Development and Technology·Upendra BulbakeWahid Khan
Mar 14, 2020·Journal of Nanobiotechnology·Márcia Cristina Oliveira da RochaSônia Nair Báo
Nov 7, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Vuk UskokovićVictoria M Wu
Jul 24, 2018·Therapeutic Advances in Urology·Darryl Ethan Bernstein, Brett Sydney Bernstein
Dec 21, 2017·Chemical Society Reviews·Chao QiPeng Huang
May 5, 2021·Colloids and Surfaces. B, Biointerfaces·Gulen Melike DemirbolatOzge Cevik

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.