Docetaxel pharmacokinetics with pre- and post-dialysis administration in a hemodyalized patient

Chemotherapy
M MencoboniR Ghio

Abstract

Docetaxel has a proven significant activity against breast, non-small cell lung, ovarian, head and neck, and hormone refractory prostate cancer. Preclinical pharmacokinetic studies have shown that hepatobiliary extraction is the major route of elimination. We conducted this study to elucidate the feasibility and safety of the use of docetaxel in hemodialysis patients. In a 72-year-old hormone refractory prostate cancer patient on hemodialysis for diabetic nephropathy for 3 years, a first dose (35 mg/m(2) iv) of docetaxel was completed 30 min before starting dialysis, while a second dose was administered 30 min after completion of a different hemodialysis session. Pharmacokinetic analysis was performed following both infusions. No apparent differences could be seen in the plasma concentration-time curves of docetaxel administered before or after dialysis. The patient experienced no significant toxicity after either administration of docetaxel. Docetaxel is safe in dialysis patients and does not require dose reduction. Dialysis does not remove this drug from blood.

References

Nov 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M T HuizingJ H Beijnen
Jan 1, 1996·Investigational New Drugs·S UrienJ P Tillement
Feb 17, 1998·Drugs·E A Eisenhauer, J B Vermorken
Mar 27, 1999·Clinical Pharmacokinetics·S J Clarke, L P Rivory
Mar 12, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G LunardiM Esposito
Dec 21, 2004·Chemotherapy·Tetsuya OguriRyuzo Ueda

❮ Previous
Next ❯

Citations

Aug 20, 2011·International Journal of Clinical Oncology·Takayuki TakimotoKinya Abe
Feb 2, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N JanusV Launay-Vacher
Mar 10, 2009·The Korean Journal of Internal Medicine·Dong Min KimChi Young Park
Jun 27, 2017·The Prostate·Megan Crumbaker, Howard Gurney
Mar 9, 2013·International Journal of Legal Medicine·Babette SchulteSibylle Banaschak
Jul 28, 2018·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·U Anido-HerranzS Vázquez

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Kathrin HocheggerWolfgang Hilbe
Annals of Oncology : Official Journal of the European Society for Medical Oncology
H IzzedineG Milano
Drug Metabolism and Disposition : the Biological Fate of Chemicals
Ken-ichi FujitaYasutsuna Sasaki
© 2022 Meta ULC. All rights reserved