Dock3 Participate in Epileptogenesis Through rac1 Pathway in Animal Models

Molecular Neurobiology
Jie LiXue-Feng Wang

Abstract

Epilepsy is one of the most common and severe neurologic diseases. The mechanisms of epilepsy are still not fully understood. Dock3 (dedicator of cytokinesis 3) is one of the new kinds of guanine-nucleotide exchange factors (GEF) and plays an important role in neuronal synaptic plasticity and cytoskeleton rearrangement; the same mechanisms were also found in epilepsy. However, little is known regarding the expression of Dock3 in the epileptic brain and whether Dock3 interventions affect the epileptic process. In this study, we showed that the expression of Dock3 significantly increased in IE patients and a lithium-pilocarpine epilepsy model compared with the controls. Inhibition of Dock3 by Dock3 shRNA impaired the severity of status epilepticus in the acute stage and decreased the spontaneous recurrent seizures times in the chronic stage of lithium-pilocarpine model and decreased the expression of rac1-GTP. Consistent with decreased expression of Dock3, the latent period in a pentylenetetrazole kindling model also increased. Our results demonstrated that the increased expression of Dock3 in the brain is associated with epileptogenesis and specific inhibition of Dock3 may be a potential target in preventing the development of e...Continue Reading

References

Mar 1, 1972·Electroencephalography and Clinical Neurophysiology·R J Racine
Dec 1, 1980·Journal of Neuroscience Methods·G PaxinosP C Emson
Feb 7, 1998·Science·A Hall
Jan 12, 2001·Physiological Reviews·Y TakaiT Matozaki
Jul 3, 2002·The Journal of Cell Biology·Qi ChenDavid Schubert
Sep 26, 2003·The New England Journal of Medicine·Bernard S Chang, Daniel H Lowenstein
Nov 26, 2003·The Journal of Biological Chemistry·Cynthia M GrimsleyKodi S Ravichandran
Jan 14, 2004·The Journal of Biological Chemistry·Kazuhiko NamekataHideo Kimura
Jun 15, 2004·Progress in Neurobiology·Kiyoshi MorimotoRonald J Racine
Nov 24, 2004·Lancet Neurology·Dougall McCorryAnthony Marson
Jan 14, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Qi ChenDavid Schubert
Oct 29, 2005·Journal of Cell Science·Nahum MellerChittibabu Guda
Jan 20, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Qian ChenZhi-Qi Xiong
Feb 24, 2007·Epilepsia·Jacqueline A French
Sep 4, 2007·Trends in Cell Biology·Jean-François Côté, Kristiina Vuori
Nov 6, 2008·Cell·Victoria Sanz-MorenoChristopher J Marshall
Jan 9, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Qi ChenDavid Schubert
Jun 12, 2009·Electrophoresis·Max GassmannJohannes Vogel
Oct 3, 2009·Cellular Signalling·Yuki Miyamoto, Junji Yamauchi
Apr 7, 2010·Proceedings of the National Academy of Sciences of the United States of America·Kazuhiko NamekataTakayuki Harada
Jan 25, 2011·Lancet Neurology·Asla Pitkänen, Katarzyna Lukasiuk
Nov 29, 2011·Experimental Neurology·Yanbing HanGuojun Chen
Jan 6, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kazuhiko NamekataTakayuki Harada
Apr 3, 2012·The American Journal of Pathology·Yali XuGuojun Chen

❮ Previous
Next ❯

Citations

Jul 19, 2016·Biochemical and Biophysical Research Communications·Yan XiongXuefeng Wang
Nov 14, 2017·American Journal of Medical Genetics. Part a·Aiko Iwata-OtsuboKosuke Izumi
Feb 8, 2020·Molecular Genetics & Genomic Medicine·Iris M de LangeBobby P C Koeleman
Apr 13, 2019·European Journal of Human Genetics : EJHG·Kimberly WiltroutMarwan Shinawi
Oct 20, 2018·Cell Death & Disease·Yi YangXuefeng Wang
Sep 12, 2020·CNS & Neurological Disorders Drug Targets·Shareen SinghAshish Kumar Rehni

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.