Docosahexaenoic acid for selective prevention of posttraumatic stress disorder among severely injured patients: a randomized, placebo-controlled trial

The Journal of Clinical Psychiatry
Y MatsuokaT Hamazaki

Abstract

Docosahexaenoic acid (DHA) might help prevent or attenuate posttraumatic stress disorder (PTSD) symptoms. We examined the efficacy and safety of DHA for preventing PTSD (DSM-IV) after severe accidental injury. From December 2008 to August 2013, we conducted a randomized, double-blind, placebo-controlled trial of 110 accident-injured patients consecutively admitted to an intensive care unit of the National Disaster Medical Center in Tokyo, Japan. All patients were taught about their psychological reactions to accidental injury for 20 minutes and were randomly assigned to receive 1,470 mg/d of DHA plus 147 mg/d of eicosapentaenoic acid (EPA; n = 53) or placebo (n = 57) for 12 weeks. The primary outcome was total score on the Clinician-Administered PTSD Scale (CAPS) at 3-month follow-up. Secondary outcomes included PTSD diagnosis (full-blown or partial PTSD). Adherence to the interventions was assessed by erythrocyte fatty acid composition. At 3 months, the CAPS total score revealed no differences between the 2 groups (10.78 in the DHA group vs 9.22 in the placebo group; n = 100; P = .572). We found that 11.1% of the DHA group and 5.5% of the placebo group developed PTSD. The erythrocyte level of DHA and EPA in the DHA group was s...Continue Reading

Citations

Aug 22, 2015·Psychopharmacology·Daisuke NishiYutaka Matsuoka
Sep 29, 2018·Nutritional Neuroscience·Ashley R PolokowskiLaura C Reigada
Oct 18, 2018·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Patrícia SantosAngelo Piato
Jan 13, 2018·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Kazuo Nakamoto, Shogo Tokuyama
Oct 28, 2019·International Journal of Molecular Sciences·Paola BozzatelloSilvio Bellino
Sep 7, 2019·Therapeutic Advances in Psychopharmacology·Madeeha Nasir, Michael H Bloch
Jan 29, 2019·Early Intervention in Psychiatry·Oliver D RobertsonSeetal Dodd
May 31, 2019·The Journal of Trauma and Acute Care Surgery·Christopher H PhamCatherine M Kuza
Aug 22, 2018·Frontiers in Physiology·Thomas Larrieu, Sophie Layé
Jul 2, 2019·Therapeutic Advances in Psychopharmacology·Arne Reimers, Hanna Ljung
Nov 21, 2017·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Hiroko NoguchiYutaka J Matsuoka
Aug 28, 2016·Journal of Affective Disorders·Giel-Jan de VriesMiranda Olff

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