PMID: 20126994Feb 4, 2010Paper

Docosahexaenoic acid intake decreases proliferation, increases apoptosis and decreases the invasive potential of the human breast carcinoma cell line MDA-MB-231

International Journal of Oncology
Vincent BlanckaertBenoît Chénais

Abstract

Breast cancer is the most common cancer in women in industrialized countries. Environmental factors, such as differences in diet are likely to have an important influence on cancer emergence. Among these factors, n-3 polyunsaturated-fatty acids, such as docosahexaenoic acid (DHA), are good candidates for preventing breast cancer. Here we investigate the effect of DHA on the human breast cancer cell line MDA-MB-231 and show that DHA incorporation i) has an anti-proliferative effect, ii) induces apoptosis via a transient increase in caspase-3 activity and the promotion of nuclear condensation, and iii) reduces the invasive potential of MDA-MB-231 cells. To conclude, DHA may have beneficial effects as a result of slowing the proliferation of tumor cells, and minimizing their metastatic potential.

Citations

Jul 20, 2012·International Journal of Breast Cancer·Benoît Chénais, Vincent Blanckaert
Jun 14, 2013·BioMed Research International·Nicolò MerendinoFrancesca Velotti
Aug 28, 2012·Advanced Drug Delivery Reviews·Michael J HackettMoo J Cho
Sep 28, 2013·Current Breast Cancer Reports·Neil M IyengarAyca Gucalp
Apr 1, 2015·International Journal of Oncology·Vincent BlanckaertBenoît Chénais
Jun 19, 2012·Molecular Nutrition & Food Research·Ailian XiongKimberly Kline
Apr 5, 2016·Chemico-biological Interactions·Christine G SkibinskiKaram El-Bayoumy
Jul 16, 2014·Pflügers Archiv : European journal of physiology·Ramez WannousStephan Chevalier
Mar 26, 2013·Toxicology Letters·Rawabi QadhiJohn M Seubert
Jun 4, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Ying-Chun WangJin-Hua Wang
Feb 2, 2018·Scientific Reports·Nathalia PizatoKelly Grace Magalhães
Apr 1, 2020·International Journal of Molecular Sciences·Cinzia GiordanoDaniela Bonofiglio
May 6, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Agata Jabłońska-TrypućAndrzej Butarewicz
Oct 18, 2019·Scientific Reports·Mégane NascimentoIsabelle Couillin
Oct 6, 2020·Frontiers in Oncology·Margherita SonnessaAnita Mangia
Nov 28, 2012·Molecular and Cellular Biochemistry·Nazila AzordeganMohammed H Moghadasian
Jul 22, 2021·Nutrition and Cancer·Olena BilykLynne-Marie Postovit
Aug 13, 2021·Frontiers in Oncology·Dengqiang WuSufang Zhou
Sep 3, 2021·Journal of Nutritional Science and Vitaminology·Yan HuXianrong Xu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Cancer: Risk Factors

Breast cancer is a multifactorial disease that is influenced by both environmental and genetic factors. Discover the latest research on the environmental and genetic risk factors for breast cancer here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.