Docosahexaenoic Acid Status in Pregnancy Determines the Maternal Docosahexaenoic Acid Status 3-, 6- and 12 Months Postpartum. Results from a Longitudinal Observational Study

PloS One
Maria Wik MarkhusIngvild E Graff

Abstract

Essential fatty acid status as well as docosahexaenoic acid (DHA, 22:6n-3) declines during pregnancy and lactation. As a result, the DHA status may not be optimal for child development and may increase the risk for maternal postpartum depression. The objective of this study was to assess changes in the maternal fatty acid status from pregnancy to 12 months postpartum, and to study the impact of seafood consumption on the individual fatty acid status. Blood samples and seafood consumption habits (gestation week 28, and three-, six- and 12 months postpartum) were collected in a longitudinal observational study of pregnant and postpartum women (n = 118). Multilevel linear modeling was used to assess both changes over time in the fatty acid status of red blood cells (RBC), and in the seafood consumption. Six fatty acids varied the most (>80%) across the four time points analyzed, including the derivative of the essential α-linoleic acid (ALA, 18:3n-3), DHA; the essential linoleic acid (LA, 18:2 n-6); and the LA derivative, arachidonic acid (AA, 20:4n-6). Over all, a large variation in individuals' DHA- and AA status was observed; however, over the 15-month study period only small inter-individual differences in the longitudinal tra...Continue Reading

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Citations

Feb 27, 2017·European Journal of Nutrition·Sigrun HenjumMarian Kjellevold
Jan 22, 2019·Journal of Pediatric Gastroenterology and Nutrition·Silvana VisentinHoracio F González
May 31, 2020·Biomolecules·Ankica SekovanićJasna Jurasović
Jun 29, 2021·Psychological Medicine·Kenta MatsumuraUNKNOWN Japan Environment and Children's Study (JECS) Group

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Methods Mentioned

BETA
PCA

Software Mentioned

Statistical Package for the Social Sciences ( SPSS Statistics
R
Qlucore Omics Explorer

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