PMID: 11328678May 1, 2001Paper

Docosahexaenoic acid supplementation-increased oxidative damage in bone marrow DNA in aged rats and its relation to antioxidant vitamins

Free Radical Research
K UmegakiK Shinozuka

Abstract

We compared the influence of docosahexaenoic acid (DHA) supplementation on oxidative DNA damage in bone marrow between young and aged rats. As a marker of oxidative DNA damage, 8-hydroxydeoxyguanosine (8-OHdG) in DNA was analyzed. Young (5-week-old) and aged (100-week-old) female Wistar rats were given DHA (300mg/kg body weight/day) or vehicle (control) orally for 12 weeks. The 8-OHdG in the bone marrow in the aged DHA group was significantly higher than that in the other groups. Vitamin E concentrations, however, did not differ among the groups regardless of the DHA supplementation. Vitamin C (ascorbic acid) concentrations in the aged control group were approximately 1/2 those in the young control group. The concentrations of vitamin C tended to be higher in the young DHA group and lower in the aged DHA group when compared to their respective control groups. Changes in the concentrations of vitamin C and vitamin E in plasma were similar to those in the bone marrow. The activity of hepatic l-gulono- gamma -lactone oxidase, an enzyme responsible for vitamin C synthesis, corresponded well to the concentrations of vitamin C in the bone marrow and the plasma. These results suggest that in aged rats, but not young rats, excess suppl...Continue Reading

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Citations

Aug 15, 2009·Clinical Biochemistry·Michelle MergenerGiovana Duzzo Gamaro
Mar 7, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Emily K FarinaKatherine L Tucker
Mar 28, 2003·Biochemical and Biophysical Research Communications·Bernd van der LooThomas F Lüscher
Apr 11, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Akihiko KatoAkira Hishida
Sep 12, 2015·Journal of the Royal Society of Medicine·Paul R Clayton, Szabolcs Ladi
Aug 26, 2003·Lipids·Daichi OikawaMitsuhiro Furuse
Mar 24, 2012·The American Journal of Clinical Nutrition·Yasumi KimuraTetsuya Mizoue
Aug 13, 2003·Biological & Pharmaceutical Bulletin·Kazuyuki HiramotoKiyomi Kikugawa
Jun 12, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·R L Corwin
Jul 3, 2021·International Journal of Molecular Sciences·Jose M Romero-MárquezJosé L Quiles

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