PMID: 8602457Mar 1, 1996Paper

Docosahexaenoic and eicosapentaenoic acids inhibit human lymphoproliferative responses in vitro but not the expression of T cell surface activation markers

Scandinavian Journal of Immunology
B KhalfounY Lebranchu

Abstract

The effects of polyunsaturated fatty acids (PUFAs: docosahexaenoic (DHA) and eicosapentaenoic (EPA) acids) on induced lymphocyte proliferation and expression of CD25alpha chain of interleukin-2 receptor, CD71 and HLA-DR were investigated. PUFAs had no effect on phytohaemagglutinin (PHA)-induced lymphocyte agglutination, but they strongly inhibited the lymphoproliferative response to PHA. This inhibitory effect is PUFA dose-dependent and seems to be more potent with DHA than EPA, Pre-incubation experiments showed that lymphocytes cultured with PUFAs for 6 h then washed and exposed to PHA, still inhibited lymphocyte proliferation. The authors also showed that this inhibitory activity was time dependent but became nonsignificant when PUFAs were added after 48 h lymphocyte culture. The addition of excess exogenous human recombinant rIL-2 partly restored PHA-lymphocyte proliferation inhibited by EPA but not by DHA. On the other hand, the authors showed that PUFAS did not inhibit IL-2 stimulated lymphocyte proliferation. The addition of PUFAs to cell culture medium had no inhibitory action on the PHA-induced lymphocyte expression of CD25, CD71 and HLA-DR. Furthermore, this effect appeared independent of eicosanoid synthesis or peroxi...Continue Reading

Citations

Nov 29, 2001·Lipids·K Duchén, B Björkstén
Oct 24, 2007·Lipids·Susan L Prescott, Janet A Dunstan
Aug 11, 2001·Microbiology and Immunology·S TeradaK S Akagawa
Mar 30, 1999·The Proceedings of the Nutrition Society·P C Calder
Jul 27, 1999·Lipids·P C Calder
Nov 26, 2008·Journal of the American Dietetic Association·Laura WardwellJeffrey Woods
Nov 24, 2004·Progress in Retinal and Eye Research·John Paul SanGiovanni, Emily Y Chew
Apr 8, 2006·Physiological Reviews·Alain Tedgui, Ziad Mallat

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