Docosahexanoic acid (DHA) improved glucose and lipid metabolism in KK-Ay mice with genetic non-insulin-dependent diabetes mellitus (NIDDM)

Biological & Pharmaceutical Bulletin
T ShimuraY Seino

Abstract

The hypoglycemic and hypolipidemic effect of docosahexaenoic acid (DHA; C22: 6omega-3) ethyl ester was examined in KK-Ay mice and neonatal streptozotocin-induced diabetic (NSZ) which are respectively obese and lean animal models of non-insulin-dependent diabetes mellitus (NIDDM), and in ddY normal mice. Single administration of DHA (500 mg/kg body weight) to KK-Ay mice significantly reduced (p<0.05) the blood glucose levels (BG) (p<0.05) and plasma free fatty acid levels (FFA) (p<0.05) at 10 h after oral administration when compared with control group. DHA (500 mg/kg body weight)-treated NSZ and normal mice, however, showed no change in these parameters. In addition, repeated administration of DHA (100 mg/kg) to KK-Ay mice significantly suppressed the increment of BG (p<0.05) and plasma triglyceride levels (TG) (p<0.01), and significantly decreased FFA (p<0.05) at 30 d compared with control group. DHA also significantly decreased the blood glucose at 60 and 120 min on insulin tolerance test (ITT). From these findings, it seems likely that DHA exhibits its hypoglycemic effects by increasing insulin sensitivity. It is concluded that DHA would be useful for treatment of obese type NIDDM with insulin resistance.

Citations

Apr 7, 2015·The Journal of Nutritional Biochemistry·Maharshi BhaswantLindsay Brown
Mar 23, 2018·Nutrients·Paloma Acosta-Montaño, Víctor García-González
Feb 29, 2008·Molecular Nutrition & Food Research·Jing-Jing LiDong Xie
Jan 19, 2008·Journal of Nutritional Science and Vitaminology·Guihua ZhangEiji Shimizu
Feb 26, 2011·The Proceedings of the Nutrition Society·S C CottinW L Hall
Aug 22, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·James A GrecoDenise D Belsham
Jul 12, 2007·Annals of Nutrition & Metabolism·Guihua ZhangEiji Shimizu
Jun 9, 2005·Journal of Atherosclerosis and Thrombosis·Masatsune SuzukiNobuhiro Yamada
Dec 22, 1999·Biochemical and Biophysical Research Communications·Y KagawaH Endo
Jun 1, 2007·Journal of Agricultural and Food Chemistry·Takayuki TsukuiKazuo Miyashita
Mar 17, 2004·The Journal of Nutritional Biochemistry·John D Radcliffe, Dorice M Czajka-Narins

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