PMID: 15227477Jan 1, 1991Paper

Documentation of experimentally induced thrombus formation using intravascular ultrasound

Texas Heart Institute Journal
J J FergusonJ T Willerson

Abstract

The purpose of the present study is to assess the ability of intravascular ultrasound to detect acute dynamic thrombus formation in canine blood vessels with damaged endothelium. Ultrasound catheters (20 MHz) were placed in the femoral arteries of anesthetized dogs, and imaging transducers were positioned at the sites of external constrictors applied to areas of endothelial injury. Flows were measured with externally applied Doppler crystals placed proximal to the constrictors. Twenty experimental procedures were performed in 18 dogs. Four procedures were performed using the InterTherapy system (4.9 Fr catheters) and 16 procedures were performed using the Boston Scientific/Diasonics system (6.0 and 4.8 Fr catheters). After injuring the endothelium by rubbing the adventitial surface with cushioned forceps, we placed the constrictors and catheters and found that femoral blood flow usually decreased to zero or near-zero over a 3- to 4-minute period. Striking the exposed artery dislodged the obstruction seen on the intravascular ultrasound images and restored flow to normal; spontaneous increases in flow associated with a reopening of the lumen were also noted. After femoral arterial blood flow returned to normal, another cycle of ...Continue Reading

References

Jun 1, 1990·The American Journal of Cardiology·N G PandianV Millen
Jul 1, 1990·Journal of the American College of Cardiology·R A NishimuraP G Yock
Jan 1, 1989·International Journal of Cardiac Imaging·J M HodgsonM J Eberle
Aug 1, 1989·American Journal of Surgery·R F NevilleM B Leon
Sep 1, 1988·The American Journal of Cardiology·N G PandianD Muller

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Citations

Jul 29, 2005·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Carlos Armando ZamoraKazuro Sugimura
Jul 1, 1992·Catheterization and Cardiovascular Diagnosis·A JainC J White

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