DoE based Olanzapine loaded poly-caprolactone nanoparticles decreases extrapyramidal effects in rodent model

International Journal of Pharmaceutics
Emil JosephRanendra N Saha

Abstract

The purpose of present investigation was to nano-encapsulate atypical antipsychotic such as Olanzapine in polymeric nanoparticles in order to explore the possibility of minimizing drug associated extrapyramidal adverse effects. The polymeric nanoparticulate systems were prepared using FDA approved polymer, polycaprolactone, by simple technique of nanoprecipitation using factorial design by DoE approach. The significant factors selected for the optimization during formulation development process were polymer content and surfactant concentration at three different levels (32 factorial design). The effect of selected significant factors were studied in depth on significant responses such as particle size and encapsulation efficiency. The optimized formulation was further surface modified with surfactant (polysorbate 80) so as to enhance the brain targeting efficiency of developed nanoparticles via endocytosis pathway. Furthermore, catalepsy was induced in rodent model and the designed formulations were investigated in comparison with pure drug solution for efficiency in decreasing extrapyramidal adverse effects. The results of in vitro characterization studies demonstrated a narrow size distributed nanoparticles (73.28 ± 2.14 nm) ...Continue Reading

Citations

Nov 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yana ZorkinaVladimir Chekhonin
Mar 7, 2021·International Journal of Biological Macromolecules·Irisvan S RibeiroRegina C M de Paula
May 23, 2020·Nanomedicine : Nanotechnology, Biology, and Medicine·Allan Radaic, Daniel Martins-de-Souza
May 21, 2018·Life Sciences·João Gomes Pontes-NetoJosé Lamartine Soares-Sobrinho
Aug 17, 2019·ACS Chemical Neuroscience·Kowthavarapu Venkata KrishnaSunil Kumar Dubey
Oct 4, 2021·Drug Discovery Today·Maria Camilla BergonziElisa Landucci

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