Does a redox cycle provide a mechanism for setting the capacity of neuroglobin to protect cells from apoptosis?

IUBMB Life
Thomas Brittain, Joanna Skommer

Abstract

We hypothesize that the various, previously reported, reactivities of neuroglobin with redox partners and oxygen provide for the establishment of a redox cycle within cells, such as neurons and retinal rod cells. Using native cell lysates, from cultured human cells of neuronal origin, we have estimated the rate of reduction of the oxidized form of neuroglobin in vivo. Furthermore we provide evidence that the cytosol of these cells contains factors (presumably enzymes) capable of employing either glutathione or NADH as re-reductants of ferric neuroglobin. Taken in conjunction with previous rate data, for the various redox reactions of neuroglobin, this information allows us to set up a computer model to estimate the steady state cellular level of the antiapoptotic ferrous form of neuroglobin. This model indicates that the steady state level of antiapoptotic neuroglobin is very sensitive to the cellular oxygen tension and moderately sensitive to the redox status of the cell. Further analysis indicates that such a system would be capable of significant modification, on the seconds time scale, following hypoxic transition, as is likely in stroke. We hypothesize that this mechanism might provide a moderately rapid mechanism for adju...Continue Reading

References

Sep 1, 2000·The British Journal of Ophthalmology·M la CourE Stefánsson
Oct 12, 2000·Nature·T BurmesterT Hankeln
May 16, 2001·Biochemistry·J T TrentM S Hargrove
Mar 7, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yunjuan SunDavid A Greenberg
Apr 5, 2005·IUBMB Life·Laurent KigerMichael Marden
Nov 8, 2005·Brain : a Journal of Neurology·Tiina SairanenPerttu J Lindsberg
May 11, 2006·Journal of Inorganic Biochemistry·Angela FagoThomas Brittain
Nov 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·Adil A KhanDavid A Greenberg
Nov 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Adil A KhanDavid A Greenberg
Apr 12, 2008·Stroke; a Journal of Cerebral Circulation·Xiaoying WangEng H Lo
Apr 29, 2008·Biochimica Et Biophysica Acta·Guy C Brown, Vilmante Borutaite
Nov 26, 2008·Nature Cell Biology·Allyson E Vaughn, Mohanish Deshmukh
Jan 22, 2009·Journal of Neurochemistry·Thi Thuy Hong DuongHugh Hamlyn Harris
Jan 16, 2010·Stroke; a Journal of Cerebral Circulation·Kunlin JinDavid A Greenberg
Jan 22, 2010·Apoptosis : an International Journal on Programmed Cell Death·Subhadip RaychaudhuriThomas Brittain
Dec 31, 2010·IUBMB Life·Thomas BrittainSubhadip Raychaudhuri

❮ Previous
Next ❯

Citations

Aug 26, 2015·International Journal of Molecular Sciences·Anyang Liu, Thomas Brittain
Jul 1, 2014·IUBMB Life·Paolo AscenziMassimo Coletta
Apr 6, 2017·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Licia PaltrinieriCarlo Augusto Bortolotti
Jul 15, 2017·Journal of Molecular Recognition : JMR·Marco FiocchettiPaolo Ascenzi
Jan 1, 2012·Cells·Thomas Brittain
Jul 22, 2018·Dalton Transactions : an International Journal of Inorganic Chemistry·Hai-Xiao LiuYing-Wu Lin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis