Does a reinforced kinetic macrocyclic effect exist? the demetallation in strong acid of copper(II) Complexes with open and cyclic tetramines containing a piperazine fragment

Chemistry : a European Journal
Massimo BoiocchiMichele Zema

Abstract

The demetallation in acidic solution of the Cu(II) complexes with open-chain and cyclic tetramines containing a piperazine unit (2 and 3) has been investigated in terms of its kinetic aspects and compared with the behaviour of unsubstituted counterparts (tetramines 1 and 4). The presence of the piperazine fragment slows demetallation of the open-chain-ligand complex owing to the activation barrier associated with the conformational change from boat-to-half-boat; however, it does not affect the demetallation of the macrocyclic complex, which involves the spontaneous boat-to-twist conformational change. Thus, lateral reinforcement of a cyclam-like ligand does not add any further contribution to the typical inertness in demetallation of macrocyclic complexes.

Citations

Dec 17, 2015·The Journal of Organic Chemistry·Bassim H AbdulwahaabStephen J Archibald
Jun 17, 2005·Organic Letters·Luigi FabbrizziAngelo Taglietti
Oct 7, 2006·Chemical Communications : Chem Comm·Matthew S Tremblay, Dalibor Sames
Feb 20, 2007·Dalton Transactions : an International Journal of Inorganic Chemistry·Jon D SilversidesStephen J Archibald
Nov 10, 2007·Dalton Transactions : an International Journal of Inorganic Chemistry·Graeme McRobbieStephen J Archibald
Jan 16, 2007·Chemical Communications : Chem Comm·Abid KhanStephen J Archibald
May 3, 2014·Chemistry : a European Journal·Vicente Martí-CentellesSantiago V Luis
Oct 13, 2006·Journal of Medicinal Chemistry·Gina C ValksStephen J Archibald

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