Does a symptom management intervention affect depression among cancer patients: results from a clinical trial

Psycho-oncology
Charles W GivenElizabeth Bowie

Abstract

Cancer patients diagnosed with solid tumors and undergoing a first course of chemotherapy were randomized to either conventional care or a 10 contact 20 week cognitive behavioral intervention designed to reduce emotional distress. Three hypotheses were tested. First, a test for a group effect found that patients in the intervention who entered the trial with higher symptom severity reported significantly lower depression at 10 but not 20 weeks. Patients in the experimental group who entered with higher depression were more depressed at 10 weeks than patients in the control group. The second hypothesis compared the intervention in two sub-indices of symptom severity; one comprised of symptoms with a depressive component, the other of symptoms not associated with depression. The intervention was more effective in lowering depression at 10 weeks through an interaction with the non-depressive symptom sub-index. At 20 weeks, a significant main effect for the intervention on depression was observed. No interaction with either sub-index was observed. The third hypothesis found no main or interaction effect between psychotropic drugs and the intervention. In conclusion, behavioral interventions may influence depression differently over...Continue Reading

References

Dec 1, 1984·Cancer·C S Cleeland
Nov 1, 1994·Cancer·D SpiegelC Koopman
Jan 1, 1996·Breast Cancer Research and Treatment·K H DowP Gulasekaram
Nov 1, 1996·Journal of Pain and Symptom Management·L GrassiM Boccalon
Apr 16, 1998·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·M R Visser, E M Smets
Sep 19, 1998·Psycho-oncology·E Bruera, C M Neumann
Apr 3, 1999·British Journal of Cancer·P StoneR A'Hern
Feb 16, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P Hopwood, R J Stephens
May 2, 2000·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·D WalshL Rybicki
Jul 11, 2000·Journal of Nursing Scholarship : an Official Publication of Sigma Theta Tau International Honor Society of Nursing·S M LeFort
Feb 17, 2001·Psycho-oncology·J ZaboraS Piantadosi
Jun 9, 2001·Journal of Pain and Symptom Management·C W GivenM Stommel
Aug 23, 2001·Journal of Pain and Symptom Management·T OkuyamaY Uchitomi
Mar 8, 2002·The Clinical Journal of Pain·Keith G WilsonPatricia C Emery
Dec 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yosuke UchitomiHitoshi Okamura

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Citations

Jun 15, 2007·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Christina LindemalmHåkan Mellstedt
Jun 15, 2010·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Charles W GivenRuth McCorkle
Mar 22, 2007·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Michela PireddaEmma Ream
Jul 2, 2010·The British Journal of Psychiatry : the Journal of Mental Science·Matthijs W BeltmanAnne E Speckens
Dec 18, 2013·Seminars in Oncology·Charles W Given, Barbara A Given
Aug 18, 2009·The Nursing Clinics of North America·Phensiri DumrongpakapakornHeidi Donovan
Jun 2, 2009·European Journal of Cancer Care·A SiddiqiA Sikorskii
Nov 7, 2006·Journal of Pain and Symptom Management·Barbara GivenMohammad Rahbar
Apr 17, 2014·Psycho-oncology·Alla SikorskiiBarbara A Given
Nov 28, 2014·Clinical Journal of Oncology Nursing·Caryl D FulcherTammie L Sherner
Apr 5, 2007·Medical Care Research and Review : MCRR·Mary D Naylor
Feb 7, 2007·Current Opinion in Psychiatry·Erin M FeketeNeil Schneiderman
Mar 26, 2019·The Cochrane Database of Systematic Reviews·Bojoura SchoutenAnn Van Hecke
Oct 16, 2019·Journal of Palliative Medicine·Frances Marcus LewisHebah Ahmed Almulla
Jan 16, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hermann FallerRoland Küffner
May 6, 2020·Journal of Psychosocial Oncology·Frances Marcus LewisAly Rice
Dec 15, 2018·Psycho-oncology·Frances Marcus LewisMary Ellen Shands
Oct 23, 2016·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Frances Marcus LewisNai-Ching Chi

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