Does acute normovolemic hemodilution reduce perioperative allogeneic transfusion? A meta-analysis. The International Study of Perioperative Transfusion.

Anesthesia and Analgesia
G L BrysonG A Wells

Abstract

The objective of this study was to systematically review the literature and to statistically summarize the evidence evaluating acute normovolemic hemodilution (ANH). Prospective, randomized, controlled trials of ANH that reported either the proportion of patients exposed to allogeneic blood or the units of allogeneic blood transfused were included. All types and languages of publication were eligible. Of 1573 identified publications, 24 trials (containing a total of 1218 patients) were included in the meta-analysis. When all trials were pooled, ANH reduced the likelihood of exposure to allogeneic blood (odds ratio [OR] 0.31, 95% confidence interval [CI] 0.15, 0.62) and the total units of allogeneic blood transfused (weighted mean difference [WMD] -2.22 U, 95% CI -3.57, -0.86). However, there was marked heterogeneity of the results. In trials using a protocol to guide perioperative transfusion, ANH failed to reduce either the likelihood of transfusion (OR 0.64, 95% CI 0.31, 1.31) or the units administered (WMD -0.25 U, 95% CI -0.60, 0.10). Adverse events were incompletely reported. It is possible that biased experimental design is, in part, responsible for the reported efficacy of this technique. after a systematic literature re...Continue Reading

References

Feb 1, 1991·Journal of Cardiothoracic and Vascular Anesthesia·J BoldtG Hempelmann
Nov 1, 1991·Transfusion·L Stehling, H L Zauder
Feb 1, 1989·Statistics in Medicine·J A BerlinT C Chalmers
Jan 1, 1987·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·J DaleJ Erikssen
Jan 1, 1986·Annales Françaises D'anesthèsie Et De Rèanimation·M C BonnetJ du Cailar
Sep 1, 1974·Anesthesia and Analgesia·N W LawsonG L Leonard
Jun 1, 1973·Annals of Surgery·J L OchsnerN Lawson
Nov 1, 1981·The Journal of Surgical Research·D Rose, T Coutsoftides
Jul 1, 1994·Acta Anaesthesiologica Scandinavica·P Van der LindenJ L Vincent
Sep 1, 1993·The Annals of Thoracic Surgery·V A FerrarisR R Klingman
Jan 1, 1993·Anesthesia and Analgesia·M M AtallahM M Saied
Mar 1, 1996·The Annals of Thoracic Surgery·G S KochambaS Khonsari
Jun 27, 1996·The New England Journal of Medicine·G B SchreiberJ J Korelitz
Feb 1, 1996·Controlled Clinical Trials·A R JadadH J McQuay

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Citations

Jun 27, 2003·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Paul G Loubser
Aug 10, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·C BaldryA Moore
Apr 13, 2007·Der Urologe. Ausg. A·O HablerB Zwissler
Feb 8, 2006·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Christopher M BlanchettePeter Kruse
Sep 3, 2011·HSS Journal : the Musculoskeletal Journal of Hospital for Special Surgery·Kathrin KleinertClément M L Werner
Jan 26, 2010·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Saifudin RashiqBarry Finegan
Jun 1, 2005·Anesthesiology Clinics of North America·B Craig Weldon
Jun 1, 2005·Anesthesiology Clinics of North America·Terri G Monk
Oct 12, 2001·Journal of Clinical Anesthesia·A Lorentz, T Frietsch
Mar 21, 2000·Transfusion Science·K T Murto, W M Splinter
Apr 22, 2003·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·Miomir-D JovićBosko P Ethukanović
Sep 12, 2003·Journal of Cardiothoracic and Vascular Anesthesia·Paul G LoubserJohn H Lemmer
Aug 31, 2002·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Uwe Kreimeier, Konrad Messmer
Oct 21, 2006·Current Opinion in Hematology·Aryeh Shander, Lawrence T Goodnough
Jun 27, 2008·The Journal of Trauma·Duncan B HughesPhilip S Barie
Dec 9, 2004·Transfusion·Aryeh Shander, Tanuja S Rijhwani
May 10, 2007·Drugs·Christian-Serge Degoute
Jan 16, 2010·Annals of Cardiac Anaesthesia·Sanjula VirmaniAshoo Wadhera
Nov 28, 2013·Archives of Orthopaedic and Trauma Surgery·M C Struijk-MulderH B Ettema
Oct 19, 2001·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·P Van der LindenG Simoens
May 14, 2014·Der Anaesthesist·C ReyherC F Weber
Jun 1, 2002·BMJ : British Medical Journal·Neil McGillRavi Gill
Aug 26, 2009·World Journal of Gastroenterology : WJG·Gianlorenzo DionigiRenzo Dionigi
Oct 17, 2009·The Heart Surgery Forum·Yuksel ElaAhmet Cekirdekci
May 28, 2008·Journal of Cardiothoracic and Vascular Anesthesia·Paul G LoubserAryeh Shander
Jul 27, 2007·Best Practice & Research. Clinical Anaesthesiology·Andreas Pape, Oliver Habler
Oct 27, 2004·Transfusion Medicine·J KaufmannS M Kasper
Sep 21, 2001·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·L WolowczykP M Lamont
Sep 27, 2003·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·L WolowczykP M Lamont
Jun 4, 2005·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·L WolowczykP M Lamont
Jul 28, 2010·Revista brasileira de anestesiologia·Marco Aurélio Beloto de SouzaLuís Vicente Garcia
Oct 27, 1999·The Journal of Surgical Research·K SingbartlG Singbartl
Apr 24, 2004·Transfusion·Jodi B SegalEliseo Guallar
Jan 25, 2007·Asian Cardiovascular & Thoracic Annals·Aflatoon Mehr-AeinManouchehr Madani-Civi

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