PMID: 18723985Aug 30, 2008Paper

Does acute promyelocytic leukemia in Indian patients have biology different from the West?

Indian Journal of Pathology & Microbiology
Pankhi DuttaRenu Saxena

Abstract

Acute promyelocytic leukemia (APML) is a well-characterized malignancy with typical clinico-hematological and molecular features. However, Indian data on this malignancy are limited. This study was conducted to determine the clinico-hematological profile of APML in India. Thirty-five patients with APML presenting to Hematology Department, AIIMS, New Delhi, between July 2003 and June 2005 were evaluated for presenting clinical features, hemogram, peripheral smear, bone marrow morphology and cytochemistry. Reverse transcriptase PCR (RT-PCR) for PML-RARalpha was done in all cases. Male-to-female ratio was 0.9:1 (males--17 and females--18) with median age 25 years (range 11-57 years). Presenting features included anemia, bleeding, fever, gum hypertrophy and scrotal ulceration. All cases showed hypergranular abnormal promyelocytes. Median hemoglobin was 6.3 g/dL (range - 3.0-9.0 g/dL), total leukocyte count (TLC) was 33.88 x 10(9) /L (range - 1-170 x 10(9) /L). Platelet count was 28 x 10(9) /L (range - 4-170 x 10(9) /L). All cases were positive for myeloperoxidase and sudan black (SB), whereas 60% cases also showed non specific esterase (NSE) positivity with 40% cases being fluoride sensitive. RT-PCR showed PML-RARalpha in 33/35 cas...Continue Reading

Citations

May 7, 2011·Journal of Ayurveda and Integrative Medicine·Balendu PrakashSanjoy K Pal
Sep 6, 2012·Drug and Chemical Toxicology·Teresa M Fonovich
Aug 13, 2010·European Journal of Clinical Investigation·Sanjeev Kumar GuptaRenu Saxena
Oct 16, 2016·Clinical Lymphoma, Myeloma & Leukemia·David Gómez-AlmaguerJosé Carlos Jaime-Pérez
Dec 3, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Sadia SultanSana Ashar

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