Does addition of low-dose aspirin and/or steroid as a standard treatment in nonselected intracytoplasmic sperm injection cycles improve in vitro fertilization success? A randomized, prospective, placebo-controlled study

Journal of Assisted Reproduction and Genetics
Candan Iltemir DuvanBulent Berker

Abstract

To investigate the effects of short-term low-dose aspirin and/or steroid use on implantation and pregnancy rates in nonselected intracytoplasmic sperm injection (ICSI) cycles. Two-hundred patients undergoing ICSI for their first cycle were enrolled in this study. Participants were then randomized into four groups on the embryo transfer day. Aspirin (100 mg/day) in group A, prednisolone (10 mg/day) in group B, aspirin along with prednisolone in group C were given while placebo was administrated to group D. There were no statistically significant differences recorded in the demographic, ovulation induction cycle characteristics between groups. Mean transferred embryo number and mean top quality embryo number were similar among study groups. There were no statistical differences in implantation and pregnancy rates between study groups. Administration of low-dose aspirin and prednisolone alone or concomitant as a standard treatment have no positive effects on implantation and/or pregnancy rates.

References

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Citations

May 8, 2008·Current Opinion in Obstetrics & Gynecology·Carolien M Boomsma, Nick S Macklon
Apr 21, 2010·Obstetrical & Gynecological Survey·Yakir SegevMartha Dirnfeld
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Jun 21, 2020·American Journal of Reproductive Immunology : AJRI·Gavin Sacks, Emma Finkelstein
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Feb 3, 2021·Human Reproduction Update·Indra Díaz-HernándezFrancisco Domínguez
Apr 24, 2021·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Ali MouradObey Albaini

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