Does adiposity mediate the relationship between physical activity and biological risk factors in youth?: a cross-sectional study from the International Children's Accelerometry Database (ICAD).

International Journal of Obesity : Journal of the International Association for the Study of Obesity
J TarpNiels C Møller

Abstract

To model the association between accumulating 60 daily minutes of moderate-to-vigorous physical activity and a composite score of biological risk factors into a direct and an indirect effect, using abdominal obesity as the mediator. Cross-sectional data from the International Children's Accelerometry Database (ICAD) including 6-18-year-old children and adolescents (N=3412) from 4 countries providing at least 3 days of accelerometry-assessed physical activity. A standardized composite risk score was calculated from systolic blood pressure and fasting blood samples of insulin, glucose, triacylglycerol and inverse HDL-cholesterol. Abdominal obesity was assessed by the waist-circumference:height ratio. Two-stage regression analysis, allowing for exposure-mediator interaction, was used for the effect decomposition. Participants achieving 60 daily minutes of moderate-to-vigorous physical activity had a 0.31 (95% CI: -0.39, -0.23) standard deviations lower composite risk score than those achieving less than 60 min. Modelling the associations suggested that 0.24 standard deviations (95% CI: -0.32, -0.16) was attributed to the direct effect and -0.07 (95% CI: -0.11, -0.02) to the indirect effect indicating that 22% of the total effect w...Continue Reading

References

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Feb 18, 2012·JAMA : the Journal of the American Medical Association·Ulf EkelundUNKNOWN International Children's Accelerometry Database (ICAD) Collaborators
May 20, 2015·Pediatrics·Emmanuel StamatakisDebbie A Lawlor
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Sep 18, 2015·Medicine and Science in Sports and Exercise·Fabiana Braga Benatti, Mathias Ried-Larsen

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Citations

Jul 22, 2019·BMC Pediatrics·Fernando Rodrigues Peixoto QuaresmaFernando Adami
Jan 23, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·André O WerneckUNKNOWN International Children’s Accelerometry Database (ICAD) Collaborators
Jan 23, 2022·The International Journal of Behavioral Nutrition and Physical Activity·Paul Remy JonesUlf Ekelund

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