Does aerobic training alleviate fatigue and improve societal participation in patients with multiple sclerosis? A randomized controlled trial

Multiple Sclerosis : Clinical and Laboratory Research
Martin HeineTREFAMS-ACE Study Group

Abstract

Evidence supporting the effectiveness of aerobic training, specific for fatigue, in severely fatigued patients with multiple sclerosis (MS) is lacking. To estimate the effectiveness of aerobic training on MS-related fatigue and societal participation in ambulant patients with severe MS-related fatigue. Patients ( N = 90) with severe MS-related fatigue were allocated to 16-week aerobic training or control intervention. Primary outcomes were perceived fatigue (Checklist Individual Strength (CIS20r) fatigue subscale) and societal participation. An improvement of ⩾8 points on the CIS20r fatigue subscale was considered clinically relevant. Outcomes were assessed by a blinded observer at baseline, 2, 4, 6 and 12 months. Of the 89 patients that started treatment (median Expanded Disability Status Scale (interquartile range), 3.0 (2.0-3.6); mean CIS20r fatigue subscale (standard deviation (SD)), 42.6 (8.0)), 43 received aerobic training and 46 received the control intervention. A significant post-intervention between-group mean difference (MD) on the CIS20r fatigue subscale of 4.708 (95% confidence interval (CI) = 1.003-8.412; p  = 0.014) points was found in favour of aerobic training that, however, was not sustained during follow-up. ...Continue Reading

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Citations

Jun 12, 2018·Multiple Sclerosis : Clinical and Laboratory Research·Morten RiemenschneiderUlrik Dalgas
Sep 17, 2019·International Journal of Rehabilitation Research. Internationale Zeitschrift Für Rehabilitationsforschung. Revue Internationale De Recherches De Réadaptation·Elisa GervasoniMarco Bove
Aug 31, 2019·Multiple Sclerosis : Clinical and Laboratory Research·Matthew Plow, Marcia Finlayson
Jan 25, 2020·European Journal of Physical and Rehabilitation Medicine·Marta Pérez de Heredia-TorresSergio Serrada-Tejeda
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Mar 5, 2021·Journal of Clinical Epidemiology·Rebecca K WebsterJeremy Howick
Mar 17, 2021·International Journal of Rehabilitation Research. Internationale Zeitschrift Für Rehabilitationsforschung. Revue Internationale De Recherches De Réadaptation·Zeynep Aykin YiğmanFatih Yiğman
May 15, 2021·La Presse médicale·Cécile Donzé, Caroline Massot
Apr 21, 2021·Multiple Sclerosis : Clinical and Laboratory Research·Anthony M HarrisonSam Norton
Jul 30, 2021·Journal of Sport and Health Science·Thomas EdwardsLara A Pilutti
Aug 11, 2021·International Journal of Sports Medicine·Yuting ChenFaming Pan
Sep 13, 2021·Archives of Physical Medicine and Rehabilitation·Ana Torres-CostosoIván Cavero-Redondo
Oct 16, 2021·Archives of Physical Medicine and Rehabilitation·Shelley S SelphMarian McDonagh

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Methods Mentioned

BETA
cognitive behavioural therapy

Clinical Trials Mentioned

ISRCTN69520623

Software Mentioned

TREFAMS
AT
SPSS

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