Does age affect prognosis in salivary gland carcinoma patients? A national Danish study

Acta Oncologica
Kristine BjørndalDanish Head and Neck Cancer Group (DAHANCA) and Academy of Geriatric Cancer Research (AgeCare)

Abstract

To compare incidence, histology, treatment modalities, disease stages, and outcome in elderly patients (≥70 years) compared to younger (<70 years). From the national Danish salivary gland carcinoma database, 871 patients diagnosed with a primary salivary gland carcinoma from January 1990 to December 2005 were identified. Variables necessary for statistical analyses were extracted from the database. The younger patients have a significantly better crude, disease-specific and recurrence-free survival than the elderly ones. In univariate analysis, significantly more patients in the young group were WHO performance status 0 and in disease stage I + II, and they presented with significantly more histological low grade tumors. In multivariate analysis, chronological age seemed to be of no prognostic significance to salivary gland carcinoma patients as opposed to performance status, disease stage and histological grade. Salivary gland carcinoma patients over the age of 70 years have a poor prognosis compared to younger patients, which can be explained by higher disease stages, more histological high grade subtypes and a poorer performance status at the time of diagnosis.

References

Mar 12, 2005·Current Opinion in Otolaryngology & Head and Neck Surgery·Wynia DerksGerrit Jan Hordijk
Jan 15, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Charlotte Rotbøl BøjeJens Overgaard

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Citations

Dec 14, 2016·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·G C ParkS Y Kim
Oct 2, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Alexander RühleNils H Nicolay
Dec 29, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Sati AkbabaNils H Nicolay
Aug 29, 2020·Brazilian Journal of Otorhinolaryngology·Osias Vieira de Oliveira FilhoFabrício Bitu Sousa

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