Does allopurinol reduce pain of chronic pancreatitis?

International Journal of Pancreatology : Official Journal of the International Association of Pancreatology
P A BanksA Slivka

Abstract

A dosage of 300 mg/d of allopurinol was not effective in reducing pain or improving activities of daily living in chronic pancreatitis. Allopurinol prevents the generation of oxygen-derived free radicals by inhibiting xanthine oxidase. The purpose of this study was to determine whether allopurinol is effective in reducing pain of chronic pancreatitis. Thirteen patients with chronic pancreatitis who were experiencing abdominal pain requiring medication at least three times each week entered a randomized, double-blind, two-period crossover clinical trial. Patients evaluated their pain daily using a categorical pain intensity scale, numeric pain intensity scale, and a visual analog scale, and weekly completed a McGill Pain Questionnaire and activities of daily living (ADL) questionnaire. The mean baseline score of pain was approx 50% of most severe pain in all scoring systems. There was no significant decrease in pain associated with allopurinol compared to the placebo (p = 0.24-0.75). In addition, there was no benefit in terms of ADL score associated with allopurinol compared with placebo (p = 0.32). Mean uric acid level was decreased by 1.15 mg/dL while patients were taking allopurinol, compared to when they were taking placebo ...Continue Reading

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Citations

May 29, 2008·World Journal of Gastroenterology : WJG·Cathia Gachago, Peter V Draganov
Sep 25, 2009·World Journal of Gastroenterology : WJG·Seyed Sajad Mohseni Salehi MonfaredMohammad Abdollahi
Sep 8, 2016·World Journal of Gastrointestinal Pharmacology and Therapeutics·Paul M HobbsDavid Y Graham
May 30, 2007·Gastroenterology Clinics of North America·Kenneth E FasanellaDavid C Whitcomb
Aug 16, 2021·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Asbjørn M DrewesJohn A Windsor
Oct 8, 2008·Antioxidants & Redox Signaling·Po Sing Leung, Yuk Cheung Chan
Feb 5, 2009·The American Journal of Gastroenterology·Luisa GuarnerJ-R Malagelada
Jan 13, 2009·British Journal of Pharmacology·Mark Connor
Feb 24, 2009·Gastroenterología y hepatología·Luisa GuarnerJorge Olsina
Nov 17, 2010·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Luca FrulloniGiuseppe Zamboni
Nov 19, 2010·Alimentary Pharmacology & Therapeutics·F BurtonUNKNOWN North American Pancreatic Study Group
Jun 17, 2011·Pain Practice : the Official Journal of World Institute of Pain·Martine PuylaertYolande C A Keulemans

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