Does AMH relate to timing of menopause? Results of an Individual Patient Data meta- analysis

The Journal of Clinical Endocrinology and Metabolism
M DepmannF J M Broekmans

Abstract

Anti-Müllerian hormone based (AMH) age at menopause predictions remain cumbersome due to predictive inaccuracy. To perform an Individual Patient Data (IPD) meta-analysis, regarding AMH based menopause prediction. A systematic literature search was performed using PubMed, Embase and Cochrane databases. Prospective cohort studies regarding menopause prediction using serum AMH levels were selected by consensus discussion. Individual cases were included if experiencing a regular cycle at baseline. Exclusion criteria were hormone use and gynecological surgery. 2596 women were included, 1077 experienced menopause. A multivariable Cox regression analysis assessed time to menopause (TTM) using age and AMH. AMH predicted TTM, however, added value on top of age was poor (age alone C-statistic 84%; age + AMH HR 0.66 95% CI 0.61-0.71, C-statistic 86%). Moreover, the capacity of AMH to predict early (≤45 years) and late menopause (≥55 years) was assessed. An added effect of AMH was demonstrated for early menopause (age alone C-statistic 52%; age + AMH HR 0.33, 95% CI 0.24-0.45, C-statistic 80%). A Weibull regression model calculating individual age at menopause revealed that predictive inaccuracy remained present and increased with decreasi...Continue Reading

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Citations

Jan 14, 2020·Thyroid : Official Journal of the American Thyroid Association·Evert F S van VelsenRobin P Peeters
Apr 19, 2019·Clinical Obstetrics and Gynecology·Nicole D Ulrich, Erica E Marsh
Aug 10, 2020·The Journal of Clinical Endocrinology and Metabolism·Loes M E Moolhuijsen, Jenny A Visser
Sep 10, 2020·Biology of Reproduction·Selva L LunaHenryk F Urbanski
Jun 12, 2019·Clinical and Experimental Reproductive Medicine·So Ra OhYeon Jean Cho
Apr 23, 2019·The Journal of Clinical Endocrinology and Metabolism·Annelien C de KatFrank J M Broekmans
Apr 10, 2020·The Journal of Clinical Endocrinology and Metabolism·H Irene SuLoki Natarajan
Oct 13, 2020·Journal of Obstetrics and Gynaecology of India·Laxmi ShrikhandeAditya Shrikhande
Jan 12, 2021·Seminars in Reproductive Medicine·Richard A Anderson, Scott M Nelson
Feb 26, 2021·Journal of Human Reproductive Sciences·Richard Fleming
Oct 19, 2019·Fertility and Sterility·Craig NiederbergerMark V Sauer
Oct 24, 2018·Journal of Gynecology Obstetrics and Human Reproduction·Mathilde VictoriaMichaël Grynberg
Sep 3, 2021·Reproductive Sciences·Aya Mohr-SassonEyal Sivan
Jul 10, 2021·Fertility and Sterility·Francesca FilippiMonica Terenziani
Sep 22, 2021·Acta Obstetricia Et Gynecologica Scandinavica·Tom G Tanbo, Peter Z Fedorcsak

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