Does amygdaloid corticotropin-releasing hormone (CRH) mediate anxiety-like behaviors? Dissociation of anxiogenic effects and CRH release

The European Journal of Neuroscience
Z MeraliH Anisman

Abstract

The brain corticotropin-releasing hormone (CRH) circuits are activated by stressful stimuli, contributing to behavioral and emotional responses. The present study assessed anxiety-like responses and in vivo neurochemical alterations at the central nucleus of the amygdala (CeA) evoked by exposure to an unfamiliar (anxiogenic) environment. Also, the impact of anxiolytic treatments and those that affect CRH were assessed in this paradigm. Novel environment (new cage) markedly suppressed ingestion of a palatable snack. This effect was dose-dependently antagonized by diazepam and was utilized as an index of anxiety in the rodent. Although exposure to a novel environment also stimulated the in vivo release of CRH and glutamate at the CeA, various CRH antagonists (e.g. alphah-CRH, Calpha-MeCRH, CP-154,526, antisauvagine-30, preproTRH178-199) did not attenuate the stressor-elicited behavioral suppression, although Calpha-MeCRH was found to attenuate the freezing response elicited by contextual stimuli that were associated with previously administered footshock. Moreover, central infusion of CRH failed to suppress snack consumption in the home cage. Although diazepam had potent anxiolytic effects in this paradigm, this treatment did not...Continue Reading

References

Feb 1, 1989·Behavioral Neuroscience·S R BodnoffM J Meaney
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Aug 1, 1972·Experimental Neurology·B Jones, M Mishkin
Oct 1, 1981·Pharmacology, Biochemistry, and Behavior·D R Britton, K T Britton
Jun 25, 1984·Brain Research·D R BrittonJ Rivier
May 1, 1994·Trends in Neurosciences·M DavisM Cassell
Nov 1, 1994·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·S C HeinrichsG F Koob
Mar 1, 1994·Pharmacology, Biochemistry, and Behavior·J C Stout, J M Weiss
Apr 1, 1996·Pharmacology, Biochemistry, and Behavior·A RexH Fink
Jan 1, 1995·Journal of Receptor and Signal Transduction Research·R M McKernanP J Whiting
Feb 1, 1997·Trends in Neurosciences·J P Herman, W E Cullinan
Jan 1, 1997·Progress in Neuro-psychopharmacology & Biological Psychiatry·T J SajdykA Shekhar
Jan 7, 1998·Neuroscience and Biobehavioral Reviews·R J BlanchardD C Blanchard
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·S C WeningerJ A Majzoub
Dec 22, 1999·Biological Psychiatry·T Steckler, F Holsboer
Feb 29, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M G SpinaG F Koob
Mar 24, 2000·Cerebral Cortex·E T Rolls
Jun 9, 2000·Annual Review of Neuroscience·J E LeDoux
Jun 29, 2000·Neuroscience and Behavioral Physiology·O G BaklavadzhyanT G Nikogosyan
Feb 13, 2001·The European Journal of Neuroscience·M E KeckR Landgraf
Jan 22, 2002·Neuroscience and Biobehavioral Reviews·L K Takahashi

❮ Previous
Next ❯

Citations

Dec 14, 2006·Psychopharmacology·Anita J BechtholtIrwin Lucki
Aug 2, 2008·Psychopharmacology·Z MeraliH Anisman
Oct 3, 2008·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Stine LasteinKjell B Døving
Apr 13, 2010·Nature Neuroscience·Ana C MagalhaesStephen S G Ferguson
Apr 3, 2009·Nature Reviews. Neuroscience·Marian Joëls, Tallie Z Baram
Dec 3, 2014·Physiology & Behavior·Jalal SolatiYulia Golub
Jul 21, 2015·Neuropharmacology·Katsukuni MitsuiSeishi Katsumata
Mar 6, 2012·Trends in Neurosciences·Pamela M Maras, Tallie Z Baram
Apr 21, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Shimon Amir, Jane Stewart
Apr 22, 2008·Neuroscience and Biobehavioral Reviews·Hymie AnismanJohn D H Stead
Apr 22, 2008·Neuroscience and Biobehavioral Reviews·Marta Weinstock
Feb 16, 2008·European Journal of Pharmacology·Aniko Korosi, Tallie Z Baram
Dec 20, 2007·The Journal of Pain : Official Journal of the American Pain Society·C Richard ChapmanChan Woo Song
Jul 3, 2007·Frontiers in Neuroendocrinology·Joseph S Lonstein
Feb 3, 2007·Neuroscience and Biobehavioral Reviews·Rianne Stam
Oct 1, 2009·The European Journal of Neuroscience·Rachel A KohmanAlexander W Kusnecov
Nov 24, 2007·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M Myslobodsky
Oct 11, 2005·Trends in Neurosciences·Jay SchulkinJeffrey B Rosen
Apr 16, 2013·Psychoneuroendocrinology·Miwa NahataHiroshi Takeda
May 17, 2014·Developmental Cognitive Neuroscience·Cheryl M McCormickJonathan J Simone
Mar 18, 2008·European Journal of Pharmacology·Yu OhmuraMitsuhiro Yoshioka
Jun 16, 2015·Frontiers in Cellular Neuroscience·Chakravarthi NarlaMichael O Poulter
May 10, 2008·Stress : the International Journal on the Biology of Stress·Kathy MichaudHymie Anisman
Nov 13, 2004·The Journal of Pharmacology and Experimental Therapeutics·Oliver StiedlJoachim Spiess
Jan 1, 2008·Gene Regulation and Systems Biology·Masanori Yoshida

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.