Does an alteration of dialyzer design and geometry affect biocompatibility parameters?

Hemodialysis International
Karel OpatrnýJ Vienken

Abstract

The aim of the study was to assess the biocompatibility profile of a newly developed high-flux polysulfone dialyzer type (FX-class dialyzer). The new class of dialyzers incorporates a number of novel design features (including a new membrane) that have been developed specifically in order to enhance the removal of small- and middle-size molecules. The new FX dialyzer series was compared with the classical routinely used high-flux polysulfone F series of dialyzers. In an open prospective, randomized, crossover clinical study, concentrations of the C5a complement component, and leukocyte count in blood and various thrombogenicity parameters were evaluated before, and at 15 and 60 min of hemodialysis at both dialyzer inlet and outlet in 9 long-term hemodialysis patients using the FX60S dialyzers and, after crossover, the classical F60S, while in another 9 patients, the evaluation was made with the dialyzers used in reverse order. The comparison of dialyzers based on evaluation of the group including all procedures with the FX60S and the group including procedures with the F60S did not reveal significant differences in platelet count, activated partial thromboplastin times, plasma heparin levels, platelet factor-4, D-dimer, C5a, an...Continue Reading

References

Jan 1, 1995·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·S K MujaisH J Gurland
Dec 1, 1993·Artificial Organs·K OpatrnýK Opatrný
Aug 1, 1995·Artificial Organs·K OpatrnýK Opatrný
Jun 1, 1996·Journal of the American Society of Nephrology : JASN·J BommerR Urbaschek
Jan 1, 1997·American Journal of Nephrology·M S ElisafK C Siamopoulos
Jan 23, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·W E BloembergenF K Port
Feb 10, 2000·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·N A HoenichS J Roberts
Mar 31, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J S TayebY Calleja
May 2, 2002·Kidney International. Supplement·Claudio RoncoGiuseppe La Greca
Jul 31, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Michael KülzHans Schneider
Jun 21, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Karel Opatrný

❮ Previous
Next ❯

Citations

Mar 17, 2010·International Urology and Nephrology·Tung-Sheng ChenYen-Lin Chang
Mar 6, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Philip Kam-Tao LiAlex Wai-Yin Yu
May 18, 2012·Kidney International·John T Daugirdas, Angelito A Bernardo
Dec 5, 2008·Hemodialysis International·Andrew Davenport
Jul 20, 2017·Artificial Organs·Aranzazu Rodríguez-SanzTeresa Bellón
Sep 14, 2012·The Cochrane Database of Systematic Reviews·Suetonia C PalmerGiovanni F M Strippoli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.