Does an Antibiotic-Loaded Hydrogel Coating Reduce Early Post-Surgical Infection After Joint Arthroplasty?

Journal of Bone and Joint Infection
Carlo L RomanòLorenzo Drago

Abstract

Background: Infection remains among the main reasons for joint prosthesis failure. Preclinical reports have suggested that antibacterial coatings of implants may prevent bacterial adhesion and biofilm formation. This study presents the results of the first clinical trial on an antibiotic-loaded fast-resorbable hydrogel coating (Defensive Antibacterial Coating, DAC(®)) in patients undergoing hip or knee prosthesis. Methods: In this multicenter, randomized prospective study, a total of 380 patients, scheduled to undergo primary (n=270) or revision (n=110) total hip (N=298) or knee (N=82) joint replacement with a cementless or a hybrid implant, were randomly assigned, in six European orthopedic centers, to receive an implant either with the antibiotic-loaded DAC coating (treatment group) or without coating (control group). Pre- and postoperative assessment of clinical scores, wound healing, laboratory tests, and x-ray exams were performed at fixed time intervals. Results: Overall, 373 patients were available at a mean follow-up of 14.5 ± 5.5 months (range 6 to 24). On average, wound healing, laboratory and radiographic findings showed no significant difference between the two groups. Eleven early surgical site infections were obse...Continue Reading

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Citations

May 18, 2018·Clinical Orthopaedics and Related Research·Arianna B LovatiCarlo L Romanò
Jun 23, 2020·Journal of Bone and Joint Infection·Volker Alt, Antonia F Chen
Jul 17, 2020·Journal of Bone and Joint Infection·Olga D SavvidouPanayiotis J Papagelopoulos
May 23, 2017·Journal of Bone and Joint Infection·C L RomanòL Drago
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Jun 20, 2019·Bone & Joint Research·C L RomanòL Drago
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Apr 8, 2021·ACS Biomaterials Science & Engineering·Deepa GargAbhay Sachdev

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Methods Mentioned

BETA
total hip arthroplasties

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