Does an increase in body mass index over 10 years affect knee structure in a population-based cohort study of adult women?

Arthritis Research & Therapy
S L BrennanA E Wluka

Abstract

Although obesity is a modifiable risk factor for knee osteoarthritis (OA), the effect of weight gain on knee structure in young and healthy adults has not been examined. The aim of this study was to examine the relationship between body mass index (BMI), and change in BMI over the preceding 10-year period, and knee structure (cartilage defects, cartilage volume and bone marrow lesions (BMLs)) in a population-based sample of young to middle-aged females. One hundred and forty-two healthy, asymptomatic females (range 30 to 49 years) in the Barwon region of Australia, underwent magnetic resonance imaging (MRI) during 2006 to 2008. BMI measured 10 years prior (1994 to 1997), current BMI and change in BMI (accounting for baseline BMI) over this period, was assessed for an association with cartilage defects and volume, and BMLs. After adjusting for age and tibial plateau area, the risk of BMLs was associated with every increase in one-unit of baseline BMI (OR 1.14 (95% CI 1.03 to 1.26) P = 0.009), current BMI (OR 1.13 (95% CI 1.04 to 1.23) P = 0.005), and per one unit increase in BMI (OR 1.14 (95% CI 1.03 to 1.26) P = 0.01). There was a trend for a one-unit increase in current BMI to be associated with increased risk of cartilage def...Continue Reading

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Citations

Apr 10, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A J GunardiA E Wluka
Jan 4, 2013·International Journal of Epidemiology·Julie A PascoMark A Kotowicz
Mar 3, 2012·The Journal of Orthopaedic and Sports Physical Therapy·Kai MithoeferStefano Della Villa
Jan 3, 2013·Arthritis Care & Research·Carrie A Karvonen-GutierrezBin Nan
Oct 15, 2013·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·V MezhovA E Wluka
Apr 30, 2013·Obesity·Julie A PascoMark A Kotowicz
Nov 30, 2013·Seminars in Arthritis and Rheumatism·Yuan Z LimFlavia M Cicuttini
May 28, 2016·International Journal of Environmental Research and Public Health·Courtney D PerryMarla Reicks
Jan 31, 2015·The American Journal of Sports Medicine·David BeckwéeIvan Bautmans
Dec 10, 2017·BMC Musculoskeletal Disorders·Alvin KengJolanda Cibere
Dec 19, 2012·Nature Reviews. Rheumatology·Anita E WlukaFlavia M Cicuttini
Jul 9, 2011·Clinical Orthopaedics and Related Research·David F DaluryTodd C Kelley

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