Does an isoniazid prophylaxis register improve tuberculosis contact management in South African children?

PloS One
Nelda van SoelenAnneke C Hesseling

Abstract

We compared the change in child household contact management of pulmonary tuberculosis (TB) cases before and after the implementation of an isoniazid preventive therapy (IPT) register in an urban clinic setting in Cape Town, South Africa. We determined if the presence of an IPT register was associated with an increase in the number of child contacts identified per infectious case and the proportion of identified children who were started on IPT. We reviewed routine programme data on IPT delivery to children during two time periods (May 2008-October 2008 and May 2011-October 2011), before and after the implementation of an IPT register used by routine clinic personnel. Adult TB case demographic and clinical characteristics from the two observation periods were similar. During the post-register period, more child contacts per adult case were identified (0.7 (54 children) vs. 0.3 (24 children)), more of the identified children were started on IPT (54 vs. 4) and 37% of those who started, completed six months of treatment compared to the pre-register period where no adherence information was recorded. After pilot implementation of an IPT register, documented identification of child contacts, IPT initiation and IPT adherence document...Continue Reading

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Citations

Jan 1, 2015·Journal of the International AIDS Society·Mary-Ann DaviesMarlène Bras
Dec 8, 2015·Journal of the International AIDS Society·Helena RabieAnthony J Garcia-Prats
Jul 25, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alexander W KayAnna M Mandalakas

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