Does angiogenesis play a role in the establishment of mesial temporal lobe epilepsy?

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
Ruba BeniniPia Wintermark

Abstract

Mesial temporal lobe epilepsy (MTLE) is a focal epileptic disorder that is frequently associated with hippocampal sclerosis. This study investigated whether blocking angiogenesis prevents the development of seizures and hippocampal atrophy in the pilocarpine rat model of MTLE. To block angiogenesis, a subset of animals were given sunitinib orally. Continuous video recordings were performed to identify seizures. Brains were then extracted and sectioned, and hippocampal surfaces and angiogenesis were assessed. After a latent period of 6.6 ± 2.6 days, the sham-treated pilocarpine rats presented convulsive seizures, while the pilocarpine rats treated with sunitinib did not develop seizures. Sham-treated pilocarpine rats but not sunitinib-treated pilocarpine rats had significantly smaller hippocampi. Endothelial cell counts in sham-treated pilocarpine rats were significantly greater than in controls and sunitinib-treated pilocarpine rats. Blocking angiogenesis immediately following the initial insult in this animal model prevented thus angiogenesis and hippocampal atrophy and averted the development of clinical seizures.

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Citations

Jan 17, 2020·Current Pharmaceutical Design·Mónica E Ureña-GuerreroCarlos Beas-Zárate
Jul 13, 2019·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Kyung-Ok ChoSeong Yun Kim
Feb 11, 2020·Frontiers in Physiology·Jugajyoti BaruahRüdiger Köhling
Apr 20, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Rick Hgj van LanenKim Rijkers
Nov 25, 2019·Epilepsy & Behavior : E&B·Victor Rodrigues SantosOlagide Wagner de Castro

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