PMID: 7544100Aug 1, 1995Paper

Does aprotinin increase the myocardial damage in the setting of ischemia and preconditioning?

The Annals of Thoracic Surgery
E A BukhariS Levitsky

Abstract

Aprotinin reduces postoperative bleeding in cardiac operations, but its association with perioperative myocardial infarction remains controversial. Ischemic preconditioning is a novel method of myocardial protection. To answer whether aprotinin increases postischemic myocardial damage and also to characterize the effect of aprotinin on ischemic preconditioning, four groups of sheep were fully heparinized to keep activated clotting time readings greater than 750 seconds and subjected to 60 minutes of normothermic regional ischemia (diagonal artery occlusion) with 3 hours of reperfusion. Group I was the control with no treatment, group II received aprotinin (1 million KIU load followed by 250,000 KIU/h), group III underwent ischemic preconditioning (three 5-minute intervals of ischemia and reperfusion) before prolonged 1-hour ischemia, and group IV underwent similar ischemic preconditioning and received aprotinin. Area at risk was delineated by monastryl blue pigment, and infarction size by tetrazolium staining. The ratios of weight of area at risk to left ventricular weight and left ventricular weight to body weight were constant between groups. Infarction size to area at risk ratio data demonstrated that aprotinin increases inf...Continue Reading

References

Jun 1, 1992·Journal of Cardiothoracic and Vascular Anesthesia·W DietrichJ A Richter
Mar 1, 1992·Circulation·S W Ely, R M Berne
Dec 1, 1991·The Thoracic and Cardiovascular Surgeon·P FeindtH Haack

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Citations

Sep 4, 1999·The Annals of Thoracic Surgery·A PavieI Gandjbakhch
Nov 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·L P PerraultJ M Moalic
Feb 11, 1998·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·J CremerA Haverich
Jun 9, 2009·British Journal of Anaesthesia·J FrässdorfW Schlack
Dec 10, 1999·The Annals of Thoracic Surgery·L P Perrault, P Menasché
Sep 11, 2012·Journal of Peptide Science : an Official Publication of the European Peptide Society·Naoki TenoYuko Tsuda
Oct 1, 2004·The Journal of Thoracic and Cardiovascular Surgery·Tanveer A KhanFrank W Sellke
Mar 23, 1999·The Annals of Thoracic Surgery·C F WippermannH Oelert
Jan 19, 2018·Anesthesia and Analgesia·Quintin J Quinones, Jerrold H Levy
Nov 30, 1999·Anesthesia and Analgesia·R J McCarthyA D Ivankovich
Jan 13, 2012·Chembiochem : a European Journal of Chemical Biology·Joakim E Swedberg, Jonathan M Harris

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