Does Armodafinil Improve Driving Task Performance and Weight Loss in Sleep Apnea? A Randomized Trial

American Journal of Respiratory and Critical Care Medicine
Julia L ChapmanNathaniel S Marshall

Abstract

Patients with obstructive sleep apnea (OSA) unable to tolerate standard treatments have few alternatives. They may benefit from weight loss, but the major symptom of daytime performance impairment may remain during weight loss programs. We hypothesized that wakefulness-promoter armodafinil would improve driving task performance over placebo in patients undergoing weight loss. This was a placebo-controlled, double-blind, randomized trial of armodafinil versus placebo daily for 6 months in patients who were also randomized to one of two diets for 6 months with follow-up at 1 year in overweight, adult, patients with OSA who had rejected standard treatment and suffered daytime sleepiness. Primary outcome was change in steering deviation in the final 30 minutes of a 90-minute afternoon driving task (AusED) at 6 months. Secondary outcomes were Epworth Sleepiness Scale, Functional Outcomes of Sleep Questionnaire, and fat mass measured by dual-emission X-ray absorptiometry. Armodafinil improved driving task performance over placebo at 3 months (12.9 cm; 95% confidence interval, 4.1-21.7; P = 0.004), but not the primary time point of 6 months (5.5 cm; 95% confidence interval, -3.3 to 14.3; P = 0.223). Patients on armodafinil lost 2.4 kg...Continue Reading

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Citations

Mar 2, 2019·Journal of Sleep Research·Joseph J Y PoonAngela L D'Rozario
Jun 28, 2019·European Respiratory Review : an Official Journal of the European Respiratory Society·Elizabeth A CayananRonald R Grunstein
Jun 13, 2018·British Journal of Hospital Medicine·Olof DahlqvistJan van der Meulen
Mar 31, 2019·Sleep & Breathing = Schlaf & Atmung·Kate SutherlandPeter A Cistulli
Jan 25, 2021·Sleep Medicine Clinics·Roo Killick, Nathaniel S Marshall

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