PMID: 6971236Feb 1, 1981Paper

Does aspirin prolong bleeding from gastric biopsies in man?

Gastrointestinal Endoscopy
J C O'LaughlinK J Ivey

Abstract

Aspirin prolongs skin bleeding time in man by inducing abnormal platelet function. Prolongation of gastric bleeding time has been postulated as a mechanism for gastric hemorrhage after aspirin in man. To determine whether endoscopic gastric biopsy is safe in patients taking aspirin, we studied the effects of acute and chronic aspirin use on gastric bleeding time in four groups of subjects. Gastric bleeding time was assessed directly following endoscopic biopsy. Skin bleeding time was done by the Mielke method. Control subjects (group I) were studied twice at one-week intervals to determine reproducibility of the gastric bleeding time technique. The effect of aspirin on gastric and skin bleeding time when given to normal volunteers for 24 hours (group II) and for two weeks (group III) and to rheumatic disease patients on a chronic basis (group IV) was also studied. In normal volunteers given aspirin for 24 hours or two weeks, gastric bleeding time was not affected in spite of skin bleeding time being significantly prolonged over baseline. Gastric bleeding time was less then skin bleeding time in all groups including patients with rheumatoid arthritis (p less than 0.05). We conclude that aspirin ingestion does not prolong gastric...Continue Reading

References

Mar 1, 1978·American Journal of Surgery·D Fromm
Oct 7, 1978·Lancet·J O'Grady, S Moncada
Mar 1, 1976·JAMA : the Journal of the American Medical Association·S E SilvisP Mandelstam
Sep 1, 1978·Annals of Internal Medicine·M TorosianH MacVaugh
Jul 1, 1979·Digestive Diseases and Sciences·J N Hunt
Oct 1, 1979·Annals of Internal Medicine·G R SilvosoJ Hewett
Sep 1, 1977·American Journal of Clinical Pathology·G R BuchananR I Handin
Jun 22, 1978·The New England Journal of Medicine·H J Weiss
Jun 15, 1978·The New England Journal of Medicine·H J Weiss
Nov 1, 1976·The American Journal of Digestive Diseases·W H MetzgerP H Guth
Jul 1, 1977·Canadian Anaesthetists' Society Journal·D W Davies, D J Steward
Jan 1, 1976·American Journal of Clinical Pathology·R L BickW R Schmalhorst
Dec 1, 1969·Circulation·E J Bowie, C A Owen
Sep 1, 1968·The Journal of Clinical Investigation·H J WeissS Kochwa

❮ Previous
Next ❯

Citations

Jan 4, 1998·Diseases of the Colon and Rectum·H NakajimaH Nara
Sep 1, 1996·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·S S De Rossi, M Glick
Jan 7, 2006·Nature Clinical Practice. Gastroenterology & Hepatology·George A Makar, Gregory G Ginsberg
Jan 3, 1991·The New England Journal of Medicine·J N George, S J Shattil
Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·B J WhittleS Moncada
Jun 17, 1999·Clinical Obstetrics and Gynecology·G M Rodgers
Mar 1, 1996·Journal of Clinical Gastroenterology·J P DayB I Hirschowitz
Jun 7, 2008·Hematology·Shir-Jing HoTimothy A Brighton
Apr 4, 2008·Gastrointestinal Endoscopy·Sun-Young LeeUNKNOWN Korean Association for the Study of Intestinal Disease
Feb 16, 2007·La Revue de médecine interne·H Lévesque
Nov 14, 1983·The American Journal of Medicine·K J Ivey
Oct 10, 1998·The Journal of the American Dental Association·R E Alexander
Nov 1, 1993·Journal of Clinical Anesthesia·N R Connelly, S Hall
Nov 4, 1985·Nature·R M Anderson, R M May
Apr 1, 1994·Alimentary Pharmacology & Therapeutics·C J Hawkey
Feb 24, 1999·Journal of Gastroenterology and Hepatology·A M MillerM L Bassett

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The American Journal of Medicine
A BarberC H Ts'ao
Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
J F Wolfaardt
© 2021 Meta ULC. All rights reserved