Does Axl have potential as a therapeutic target in pancreatic cancer?

Expert Opinion on Therapeutic Targets
Wenting Du, Rolf A Brekken

Abstract

Pancreatic cancer is a leading cause of cancer-related death. Metastasis, therapy resistance, and immunosuppression are dominant characteristics of pancreatic tumors. Strategies that enhance the efficacy of standard of care and/or immune therapy are likely the most efficient route to improve overall survival in this disease. Areas covered: Axl, a member of the TAM (Tyro3, Axl, MerTK) family of receptor tyrosine kinases, is involved in cell plasticity, chemoresistance, immune suppression, and metastasis in various cancers, including pancreatic cancer. This review provides an overview of Axl and its function in normal conditions, summarizes the regulation and function of Axl in cancer, and highlights the contribution of Axl to pancreatic cancer as well as its potential as a therapeutic target. Expert opinion: Axl is an attractive therapeutic target in pancreatic cancer because it contributes to many of the roadblocks that hamper therapeutic efficacy. Clinical evidence supporting Axl inhibition in pancreatic cancer is currently limited; however, multiple clinical trials have been initiated or are in the planning phase to test the effect of inhibiting Axl in conjunction with standard therapy in pancreatic cancer patients. We antici...Continue Reading

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Citations

May 14, 2019·Oncotarget·Mai Tanaka, Dietmar W Siemann
Feb 24, 2020·Cell Communication and Signaling : CCS·Adam S Dayoub, Rolf A Brekken
Nov 5, 2019·Frontiers in Oncology·Emily N ArnerRolf A Brekken
Oct 1, 2020·Targeted Oncology·Mitchell S von ItzsteinMuhammad Shaalan Beg
Feb 7, 2021·Journal of Clinical Medicine·Andres Garcia-SampedroPilar Acedo
Dec 29, 2020·Expert Opinion on Therapeutic Targets·Pavlos MsaouelNizar M Tannir
Apr 4, 2021·Molecular Cancer Research : MCR·Wenting DuRolf A Brekken
Oct 23, 2021·Molecular Cancer Therapeutics·Yuqing ZhangRolf A Brekken

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