PMID: 15230284Jul 3, 2004Paper

Does B cell depletion have a role to play in the treatment of systemic lupus erythematosus?

Lupus
C GormanD Isenberg

Abstract

B cell dysfunction and pathogenic autoantibody formation are thought to be critical in the pathogenesis of systemic lupus erythematosus (SLE). In this review we will summarize the results of attempts to utilize B cell depletion, based on the use of a chimeric monoclonal antibody (MAb) specific for human CD20, rituximab, for the treatment of patients with SLE.

References

Sep 1, 1994·Immunology Today·T F Tedder, P Engel
Jan 16, 1999·Baillière's Clinical Rheumatology·L J Mason, D A Isenberg
Mar 25, 2000·Annals of the Rheumatic Diseases·G S DeanD A Isenberg
Mar 10, 2001·Joint, Bone, Spine : Revue Du Rhumatisme·D Emilie, X Mariette
Sep 14, 2002·Annals of the Rheumatic Diseases·M J LeandroG Cambridge
Oct 9, 2002·Scandinavian Journal of Rheumatology·D Isenberg, M J Leckie
Oct 18, 2002·Arthritis and Rheumatism·Maria J LeandroDavid A Isenberg

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Citations

Jul 21, 2009·Modern Rheumatology·Petros Efthimiou, Michelle Blanco
Jun 1, 2005·Rheumatic Diseases Clinics of North America·John G Hanly
Mar 1, 2010·Reumatología clinica·Rosa Elena Calderón SaldiernaAriana Maia Becerra Márquez
Mar 1, 2006·Rheumatic Diseases Clinics of North America·R John LooneyIñaki Sanz
Nov 24, 2006·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Utako KanekoMakoto Uchiyama
Oct 27, 2006·Joint, Bone, Spine : Revue Du Rhumatisme·Alessandra Bruns, Olivier Meyer
May 16, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·William Stohl, R John Looney
Sep 10, 2005·Best Practice & Research. Clinical Rheumatology·John G Hanly, Melanie J Harrison
Jul 26, 2006·Pharmacology & Therapeutics·Andrew P R SutherlandCharles R Mackay
Jul 27, 2007·Journal of Immunological Methods·H BlascoC Le Guellec
Apr 6, 2005·Lupus·S Vasoo, G R V Hughes
Jul 11, 2008·Immunological Reviews·Koichi YanabaThomas F Tedder
Jun 12, 2009·Journal of Interprofessional Care·Jeannie Scruggs GarberJoyce J Fitzpatrick
Aug 19, 2011·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Michelle S FortierDiane Culver
Sep 11, 2014·Journal of Interprofessional Care·Alfonso SollamiLeopoldo Sarli

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