PMID: 9444975Aug 1, 1997Paper

Does base composition help predispose the complementarity-determining regions of antibodies to hypermutation?

Molecular Immunology
E A Padlan

Abstract

A survey of the base usage in genes coding for human antibodies reveals that more (A+T) and less (C+G) are found in the segments coding for the complementarity-determining regions, while the opposite is true for the segments coding for framework and constant regions. The possibility that this bias in base usage may contribute to hypermutation is explored.

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Citations

Mar 19, 2002·Scandinavian Journal of Immunology·S S Saini, A Kaushik
Aug 13, 2004·Proceedings of the National Academy of Sciences of the United States of America·Frederic A FellouseSachdev S Sidhu
Apr 14, 2005·Journal of Molecular Biology·Christopher J BondSachdev S Sidhu
Apr 28, 2005·Journal of Molecular Biology·Frederic A FellouseSachdev S Sidhu

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