Does baseline total testosterone improve the yielding of prostate cancer screening?

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Francisco BotelhoNuno Lunet

Abstract

Previous studies suggest an association between total testosterone (tT) and prostate cancer, but results are conflicting and it is not clear if accounting for the tT levels improves the yielding of patient selection for prostatic biopsy. We evaluated the potential for tT levels and the tT/total PSA (tPSA) ratio to be used as diagnostic tools for prostate cancer and its relation with cancer aggressiveness. We measured tT, tPSA and free PSA (fPSA) in fasting blood samples of 1570 subjects consecutively referred for prostate biopsy due to abnormal digital rectal examination and/or elevated tPSA levels. These values were compared between groups defined according to the pathological results of the biopsy. No significant difference was observed in tT levels when comparing cases with prostate cancer, high grade prostate intraepithelial neoplasia, pathological prostatitis, benign prostatic hyperplasia or no alteration (median: 4.26 versus 4.44 versus 4.31 versus 4.16 pg/mL, respectively; p=0.643). The tT/tPSA ratio had a better area under the curve than tT alone (0.62, 95% CI, 0.59-0.65 versus 0.50, 95% CI, 0.47-0.53), but worse than the f/tPSA ratio (0.70, 95% CI, 0.67-0.73). In multivariate analysis, using the median of distribution ...Continue Reading

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Citations

Feb 18, 2014·Clinical Biochemistry·Frank FriedersdorffCarsten Stephan
Mar 12, 2017·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Aksam YassinDany-Jan Yassin
Dec 2, 2015·Therapeutic Advances in Urology·Jason E MichaudAlan W Partin
Oct 20, 2017·Endocrine-related Cancer·Takeshi UjikeNorio Nonomura

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