PMID: 9655523Jul 9, 1998Paper

Does beta-carotene protect membrane lipids from nitrogen dioxide?

Free Radical Biology & Medicine
S M KhopdeR K Bhattacharya

Abstract

Lipid peroxidation in rat liver microsomes, induced by nitrogen dioxide (NO2), a free radical toxin, was examined in the absence and in the presence of varying concentrations of beta-carotene. The extent of peroxidation was assayed by determining the malonaldehyde formed as thiobarbituric acid reactive substances (TBARS). When the concentration of beta-carotene was 13.8 and 43.1 nmol/mg protein, no protection was seen, rather an increase of 10% and 30%, respectively, in TBARS was observed as compared with the normal microsomes containing no beta-carotene. However, at beta-carotene concentrations of 66.5 and 89.4 nmol/mg protein, only a marginal increase of 9% and 4% in TBARS, respectively, was observed. The amount of beta-carotene consumed during peroxidation, determined by following the absorbance at 450 nm, was found to increase linearly with increased exposure to NO2. The direct reaction of NO2 with beta-carotene was studied in an inert organic solvent, acetonitrile, by following the absorption spectrum of beta-carotene in the wavelength region 220-600 nm. The rate of loss of beta-carotene was found to be much faster than that in microsomes. The results suggest that in in vitro systems, the reaction of secondary lipid-derive...Continue Reading

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Citations

Oct 18, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Shu-Lan Yeh, Miao-Lin Hu
Jul 30, 2003·Mycological Research·George ZervoudakisChristos D Georgiou
May 30, 2002·Biological Chemistry·Michael KirschHerbert de Groot
Aug 21, 2014·Oxidative Medicine and Cellular Longevity·Borut Poljšak, Rok Fink
Aug 18, 2005·Phytotherapy Research : PTR·T K ShettyC K K Nair
Sep 21, 2006·Redox Report : Communications in Free Radical Research·Stuart G JarrettMike Boulton
Sep 25, 2001·Fungal Genetics and Biology : FG & B·C D GeorgiouM Kornaros
Apr 5, 2000·Nutrition Reviews·W A PryorC L Rock
Jul 3, 1999·Nutrition Reviews·D A CooperJ C Peters
Mar 6, 2010·The Journal of Physical Chemistry. B·J P Cerón-CarrascoB Miguel
Mar 21, 2002·Journal of Agricultural and Food Chemistry·K Indira PriyadarsiniHari Mohan

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