Does body-coil magnetic-resonance imaging have a role in the preoperative staging of patients with clinically localized prostate cancer?

BJU International
Darrell J AllenRick Popert

Abstract

To investigate the accuracy and use of body-coil magnetic resonance imaging (MRI) in the local staging of prostate cancer before radical prostatectomy (RP). Fifty-six patients undergoing RP were staged before surgery using body-coil MRI; none was denied surgery on the basis of their scan results. All scans were reported before RP by one of three consultant radiologists and afterward by a colleague with a special interest in prostate MRI, unaware of the patients' clinical details. The overall sensitivity of MRI at detecting extracapsular extension was 50% on general reporting and 72% when reported by the specialist radiologist; the respective specificities were 84% and 86%. Of the 55 patients included in the study, 18 (33%) had extracapsular disease on histological analysis. MRI was most accurate in the 17 patients at high-risk (prostate-specific antigen, PSA, >10 ng/mL and Gleason score >or= 8) and eight at intermediate risk (PSA < 10 ng/mL and Gleason score 7). In the former group with specialist analysis, the sensitivity was 100%, although this decreased to 67% with general reporting. Both gave a specificity of 82%. Intermediate risk disease gave a sensitivity and specificity of 75%, irrespective of reporting method. The abil...Continue Reading

References

Jan 1, 1993·Seminars in Roentgenology·P Ramchandani, M D Schnall
Sep 1, 1997·The Journal of Urology·G J O'DowdJ E Oesterling
Feb 25, 1998·The Journal of Urology·S IkonenS Rannikko
Aug 27, 2002·European Radiology·Marc R EngelbrechtJelle O Barentsz

❮ Previous
Next ❯

Citations

Nov 30, 2005·Topics in Magnetic Resonance Imaging : TMRI·Thomas C Lauenstein, Richard C Semelka
Aug 10, 2010·Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada·Brian KimChris Morash
Dec 25, 2008·The Prostate·Pal KissGabriel A Elgavish
Nov 12, 2013·Diagnostic and Interventional Imaging·P PuechL Lemaitre
Aug 5, 2006·Journal of Magnetic Resonance Imaging : JMRI·Thomas C Lauenstein, Richard C Semelka
Apr 9, 2005·Current Opinion in Urology·Stephen A BrassellDavid G McLeod

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cajal Bodies & Gems

Cajal bodies or coiled bodies are dense foci of coilin protein. Gemini of Cajal bodies, or gems, are microscopically similar to Cajal bodies. It is believed that Cajal bodies play important roles in RNA processing while gems assist the Cajal bodies. Find the latest research on Cajal bodies and gems here.