Does brain functional connectivity contribute to musculoskeletal injury? A preliminary prospective analysis of a neural biomarker of ACL injury risk

Journal of Science and Medicine in Sport
Jed A DiekfussGregory D Myer

Abstract

We aimed to present a unique prospective neurological dataset for participants who experienced an ACL injury. Prospective longitudinal case-control. High school female soccer athletes were evaluated using functional magnetic resonance imaging to capture resting-state brain connectivity prior to their competitive season. Two of these athletes later experienced an ACL injury (ACLI). We matched these ACLI participants with eight teammates who did not go on to sustain an ACL injury (uninjured controls, Con) based on age, grade, sex, height, and weight to examine differences in preseason connectivity. Knee-motor regions of interest (ROIs) were created based on previously published data from which five specific areas were selected as seeds for analysis. Independent-samples t-tests with a false discovery rate correction for multiple comparisons determined differences in connectivity between the ACLI and Con. There was significantly greater connectivity between the left primary sensory cortex (a brain region responsible for proprioception) and the right posterior lobe of the cerebellum (a brain region responsible for balance and coordination) for the Con relative to ACLI, t (8)=4.53, p=0.03 (false discovery rate corrected). These preli...Continue Reading

Citations

Dec 7, 2018·The Journal of Orthopaedic and Sports Physical Therapy·Justin M LoscialeTimothy C Sell
Jul 5, 2019·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Dustin R GroomsGregory D Myer
Jun 22, 2021·Physical Therapy in Sport : Official Journal of the Association of Chartered Physiotherapists in Sports Medicine·Joann M WalkerDustin R Grooms
Jul 26, 2021·Journal of Science and Medicine in Sport·Jan Wilke, David A Groneberg
Aug 12, 2021·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jed A DiekfussGregory D Myer

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