Does cadmium exposure contribute to depressive symptoms in the elderly population?

Occupational and Environmental Medicine
Changwoo HanYun-Chul Hong

Abstract

To date, the association of the neurotoxic agent cadmium (Cd) with depression in elderly people has been poorly evaluated. By investigating the relationship between blood cadmium levels and scores on a depression screening test, we aimed to investigate the impact of cadmium exposure on elderly depression. From 2008 to 2010, a total of 395 elderly participants residing in Seoul, Korea, were evaluated 3 times. Demographic data and lifestyle information were obtained via a systemised questionnaire, and blood samples were collected for analysis. Participants underwent the Korean Version of the Short Form Generic Depression Scale test (SGDS-K) for screening depression and associations were estimated using logistic regression models adjusted for potential confounders. Blood cadmium levels were associated with depressive symptoms in the first visit data analysis. By analysing the first visit data, the highest quartile blood cadmium group (Q4) showed increased risk for depressive symptoms compared to the lowest quartile group (Q1) (OR 3.50, 95% CI 1.22 to 10.00). However, the data of the second and third visits suggested that blood cadmium may be protective against depressive symptoms (second visit data, Q4 vs Q1, OR 0.78, 95% CI 0.19 ...Continue Reading

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Citations

Mar 19, 2016·Occupational and Environmental Medicine·Changwoo HanYun-Chul Hong
Feb 21, 2016·Occupational and Environmental Medicine·Tomoyuki Kawada
Oct 18, 2016·Journal of Preventive Medicine and Public Health = Yebang Ŭihakhoe Chi·Changwoo HanYun-Chul Hong
Jan 12, 2019·Annual Review of Public Health·Matilda van den Bosch, Andreas Meyer-Lindenberg
Jun 14, 2020·Current Environmental Health Reports·Aisha S DickersonMarc Weisskopf
Apr 17, 2021·Ecotoxicology and Environmental Safety·Anna Maria CybulskaElżbieta Grochans

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