Does carbonation of steel slag particles reduce their toxicity? An in vitro approach

Toxicology in Vitro : an International Journal Published in Association with BIBRA
Saloua IbouraadatenDominique Lison

Abstract

Mineral carbonation can stabilize industrial residues and, in the steel industry, may contribute to simultaneously valorize CO2 emissions and slag. We hypothesized that, by restricting the leaching of metals of toxicological concern such as Cr and V, carbonation can suppress the toxicity of these materials. The cytotoxic activity (WST1 assay) of slag dusts collected from a stainless and a Linz-Donawitz (LD) steel plant, before and after carbonation, was examined in J774 macrophages. The release of Cr, V, Fe, Mn and Ni was measured after incubation in artificial lung fluids mimicking the extracellular and phagolysosomal milieu to which particles are confronted after inhalation. LD slag had the higher Fe, Mn and V content, and was more cytotoxic than stainless steel slag. The cytotoxic activity of LD but not of stainless dusts was reduced after carbonation. The cytotoxic activity of the dusts toward J774 macrophages necessitated a direct contact with the cells and was reduced in the presence of inhibitors of phagocytosis (cytochalasin D) or phagolysosome acidification (bafilomycin), pointing to a key role of metallic constituents released in phagolysosomes. This in vitro study supports a limited reduction of the cytotoxic activit...Continue Reading

References

Sep 2, 2003·Journal of Environmental Monitoring : JEM·Woodhall StopfordTom Brock
Apr 13, 2005·Waste Management·T Van GervenC Vandecasteele
May 19, 2006·Journal of Hazardous Materials·Perrine ChaurandJean-Yves Bottero
Mar 3, 2010·International Journal of Environmental Research and Public Health·Mihee LimKwang-Suk You
Jun 24, 2010·Environmental Science & Technology·Carla NavarroMaría A Villa-García
Jul 23, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·William M GwinnDaniel L Morgan

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Citations

Sep 20, 2019·Particle and Fibre Toxicology·Violaine SironvalSybille van den Brule

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