PMID: 2116743Aug 1, 1990Paper

Does cardiopulmonary bypass alter enflurane requirements for anesthesia?

Anesthesiology
R I Hall, J A Sullivan

Abstract

This study on dogs determined whether the requirement for enflurane anesthesia was different pre- versus postcardiopulmonary bypass (CPB). Male mongrel dogs (n = 16) were anesthetized with enflurane in oxygen. Tracheal intubation was performed, monitors placed, and end-tidal enflurane concentration measured via a Puritan-Bennett Anesthesia Agent Monitor. MAC was determined by the tail-clamp method. CPB was then initiated using aortoatrial (n = 6, group 1) or femoral artery-vein (n = 4, group 2) cannulation or none (n = 6, group 3, control). CPB was maintained for 1 h using a bubble oxygenator, a crystalloid prime, and flows of approximately 70-80 ml/kg with a mean systemic pressure maintained between 50-70 mmHg. Following separation from CPB, MAC was again determined. The reduction in enflurane MAC following CPB was 30.1 +/- 21.5% (mean +/- SD; P less than 0.05 vs. pre-CPB) in group 1 but there was a wide range of reduction produced (3.8-58.8%). The degree of MAC reduction (19.8 +/- 8.6%; P less than 0.05 vs. pre-CPB) produced by CPB in group 2 was much less variable in degree (range 13.0-32.4%) but did not differ from group 1. Although pre- versus post-CPB mean systemic pressure fell from 83 +/- 13 to 69 +/- 15 mmHg (P less th...Continue Reading

Citations

Sep 1, 1991·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·R Hall
Dec 1, 1993·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·R I Hall
Feb 1, 1993·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·G J DoakJ A Sullivan
Nov 14, 1997·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·M W NeumeisterR I Hall
Feb 21, 2002·Journal of Cardiothoracic and Vascular Anesthesia·Richard I Hall
Dec 4, 2004·Journal of Cardiothoracic and Vascular Anesthesia·Hong YangHilary P Grocott
Apr 1, 1992·Journal of Cardiothoracic and Vascular Anesthesia·B P KavanaghS V Lichtenstein
Nov 1, 2001·Journal of Cardiothoracic and Vascular Anesthesia·J C LundellJ F Butterworth

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