Does central nitric oxide chronically modulate the acute hypoxic ventilatory response in conscious rats?

Acta Physiologica
D O SchwenkeM Shirai

Abstract

Hypoxia initiates an increase in ventilation (VE) through a cascade of events of which central nitric oxide (NO) has been implicated as an important neuromodulator. There have not been any reports describing the consequences of long-term imbalances in the central NO pathways on the modulation of the acute hypoxic ventilatory response (HVR). Chronic hypoxia (CH) can potentially modify the HVR, and so we hypothesized that central NO may be involved. In this study we describe the long-term role of central NO in the modulation of HVR before and after CH. Male Sprague-Dawley rats (BW c. 200-320 g; n = 21) were implanted with an osmotic pump for continuous intracerebroventricular administration of either artificial cerebrospinal fluid (control), Nomega-nitro-L-arginine methyl ester (L-NAME) (150 microg kg(-1) day(-1)) or the NO-donor, 3-[4-morpholinyl]-sydnonimine-hydrochloride (SIN-1) (100 microg kg(-1) day(-1)). The VE response to acute poikilocapnic hypoxia (8% O2 for 20 min) was measured by plethysmography seven days after surgery, in normoxia, and again after 14 days of exposure to CH (CH = 12% O2). The magnitude of the HVR (c. 230% increase in VE) was unaltered by centrally infusing either L-NAME or SIN-1 for 1 week. CH did not...Continue Reading

References

Jul 1, 1979·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·R W ChapmanN H Edelman
Oct 28, 1991·Neuroscience Letters·L N ShapovalL S Pobegailo
Jul 1, 1989·Journal of Applied Physiology·R A WachG R Barer
Jun 30, 1988·Biochemical and Biophysical Research Communications·R M PalmerS Moncada
Feb 1, 1973·Journal of Applied Physiology·R D Buñag
Oct 1, 1970·Respiration Physiology·D Bartlett, S M Tenney
Jan 1, 1982·Physiological Reviews·J A Dempsey, H V Forster
Oct 15, 1993·The Journal of Comparative Neurology·Z Z WangL J Stensaas
May 1, 1994·Neuroscience·Z Z WangS J Fidone
Oct 15, 1993·Brain Research·N R PrabhakarM A Haxhiu
May 7, 1993·Brain Research·J E Buchanan, J W Phillis
Apr 1, 1993·Journal of Applied Physiology·E A Aaron, F L Powell
Sep 1, 1995·Respiration Physiology·M A HaxhiuN S Cherniack
May 1, 1997·American Journal of Respiratory and Critical Care Medicine·D GozalP J Hornby
Oct 10, 1997·The American Journal of Physiology·L G BrancoR C Barros
Apr 16, 1998·Journal of Applied Physiology·P J OhtakeD Gozal
Jul 14, 1998·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Y WadaT Imaizumi
Apr 13, 1999·The American Journal of Physiology·K SatoI F McMurtry
Jul 20, 1999·Journal of Applied Physiology·H Gautier, C Murariu
Jun 13, 2000·Advances in Experimental Medicine and Biology·D D Kline, N R Prabhakar
Aug 30, 2000·Respiration Physiology·F L PowellM R Dwinell
Aug 14, 2001·American Journal of Respiratory and Critical Care Medicine·H NakanoG A Farkas
Feb 14, 2002·Journal of Applied Physiology·Renata C H Barros, Luiz G S Branco
Aug 17, 2002·Journal of Applied Physiology·Shyam SubramanianKingman P Strohl
Dec 18, 2002·Journal of Applied Physiology·Gordon S Mitchell, Stephen M Johnson
Jul 23, 2003·Neuroscience Letters·Luciane H GargaglioniLuiz G S Branco
Aug 20, 2005·Journal of Applied Physiology·Stephen G Reid, Frank L Powell
Jan 13, 2006·Clinical and Experimental Pharmacology & Physiology·Daryl O SchwenkeMikiyasu Shirai

❮ Previous
Next ❯

Citations

Sep 13, 2008·Respiratory Physiology & Neurobiology·Stephen R ReevesDavid Gozal
Nov 17, 2006·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Daryl O SchwenkePatricia A Cragg
Mar 24, 2016·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C DiongD O Schwenke
Apr 19, 2015·Respiratory Physiology & Neurobiology·Zhenzhong BaiAurélien P Pichon
Jul 31, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Aurélien PichonRi-Li Ge
Apr 16, 2010·Physiological Reviews·Luc J Teppema, Albert Dahan
Dec 25, 2019·Nitric Oxide : Biology and Chemistry·Taiming LiuArlin B Blood

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.