Does colloid-induced plasma hyperviscosity in haemodilution jeopardize perfusion and oxygenation of vital organs?

Acta Anaesthesiologica Scandinavica
H KrieterK Messmer

Abstract

The infusion of dextran solutions is associated with haemodilution and, under some conditions, with a slight increase in plasma viscosity. To clarify the compound effects of simultaneous haemodilution and plasma viscosity increases on macro- and microhaemodynamics, we investigated the changes in arterial perfusion (radiolabelled microspheres, 15 microns ø) and oxygenation (tissue Po2) of vital organs using an animal model of plasma hyperviscosity. In nine splenectomized beagles plasma viscosity was increased step by step from 1.06 (baseline) to 2.14, and 2.99 mPa.s by infusion of small amounts (4% of total blood volume) of an ultra-high-molecular-weight dextran (50% w/v, mw: 500,000). Despite the significant increase in plasma viscosity, cardiac output as well as specific organ blood flows in heart, brain, liver, and muscle rose steadily with each step of viscosity, while the haematocrit declined from 0.31 to 0.24 and 0.20, respectively. Medians of tissue Po2 in liver peaked at a viscosity of 2 mPa.s and returned to baseline values at 3 mPa.s, whereas in non-working skeletal muscle Po2 values were maximal at 3 mPa.s. These results indicate that the impact of plasma viscosity on the rheological properties of whole blood is compl...Continue Reading

References

Jan 1, 1991·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·B ZwisslerK Messmer
Oct 1, 1990·Computer Methods and Programs in Biomedicine·W GrossK Messmer
Jan 1, 1989·Clinical Immunology and Immunopathology·D MatourD M Murasko
Aug 1, 1965·Proceedings of the Society for Experimental Biology and Medicine·S ChienM I Gregersen

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Citations

Jul 3, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·J MühlingG Hempelmann
Jul 13, 2006·Annual Review of Biomedical Engineering·Marcos IntagliettaAmy G Tsai
Jan 12, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Pedro CabralesAndre F Palmer
Apr 22, 2015·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Surapong ChatpunPairaya Rujirojindakul
Jul 14, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C LenzK F Waschke
Jan 6, 2009·Transfusion Alternatives in Transfusion Medicine : TATM·C LenzT Frietsch
Feb 12, 2011·Biotechnology Progress·Jacob ElmerAndre F Palmer
May 12, 2004·Critical Care Clinics·Paul C HébertLing Qun Hu
Mar 23, 2005·Anesthesia and Analgesia·Michael P W GrocottTong J Gan
Mar 7, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Pedro CabralesAmy G Tsai
May 30, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Pedro Cabrales, Amy G Tsai
Mar 25, 2009·Current Opinion in Anaesthesiology·Nivaldo R VillelaMarcos Intaglietta
Jul 20, 1999·Journal of Applied Physiology·S DeemE R Swenson
Dec 9, 1998·The American Journal of Physiology·A G TsaiM Intaglietta

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