Does comorbid anxiety or depression affect clinical outcomes in patients with post-traumatic stress disorder and alcohol use disorders?

Comprehensive Psychiatry
Lawrence A LabbateKathleen T Brady

Abstract

Post-traumatic stress disorder (PTSD) is commonly comorbid with other psychiatric disorders, including substance use disorders. In spite of this, pharmacologic treatment trials for PTSD often exclude individuals with significant psychiatric comorbidity. This study is a post hoc analysis of a 12-week double-blind placebo-controlled trial investigating sertraline in the treatment of patients with comorbid PTSD and an alcohol use disorder. Individuals with additional anxiety and affective disorders were included. Patients (N = 93) were stratified into four groups depending on presence or absence of additional anxiety or depressive disorders and evaluated for the effects of comorbidity on PTSD symptoms, depressive symptoms, and drinking behaviors. We hypothesized that additional comorbidity would be associated with poorer outcomes. Patients in all four subgroups showed marked and clinically significant improvement in alcohol drinking behaviors over the course of the study. For the entire sample, over the course of the 12 weeks, mean drinks per drinking day fell from 13.0 +/- 8.4 (SD) to 3.0 +/- 5.0 (SD); t = 10.2, df = 92, P <.000. There were, however, no significant differences among groups. Patients in all four groups showed mode...Continue Reading

References

Mar 1, 1991·Archives of General Psychiatry·N BreslauE Peterson
Mar 1, 1990·Archives of General Psychiatry·J DavidsonJ O Cavenar
Dec 1, 1995·Archives of General Psychiatry·R C KesslerC B Nelson
Jan 1, 1995·Journal of Traumatic Stress·D D BlakeT M Keane
Oct 1, 1996·The American Journal of Psychiatry·C BrownP R Houck
Nov 1, 1996·Alcoholism, Clinical and Experimental Research·R M Kadden
Jun 1, 2000·The American Journal of Psychiatry·U FeskeD J Kupfer
Aug 17, 2000·JAMA : the Journal of the American Medical Association·B A JohnsonJ Hensler
Dec 1, 2000·Depression and Anxiety·J Kaufman, D Charney
Apr 11, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·K M ConnorJ R Davidson
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Sep 25, 2003·Comprehensive Psychiatry·Kathleen T Brady, Cathryn M Clary

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Citations

Oct 9, 2007·Current Opinion in Psychiatry·Ingo Schäfer, Lisa M Najavits
Jul 15, 2015·Journal of Trauma & Dissociation : the Official Journal of the International Society for the Study of Dissociation (ISSD)·Hwallip BaeYong Chon Park
Oct 11, 2011·Addictive Behaviors·Thomas M KellyAntoine B Douaihy
Apr 14, 2010·The Psychiatric Clinics of North America·Shelly F GreenfieldKathleen T Brady
Dec 9, 2008·Drug and Alcohol Dependence·John S CacciolaJames R McKay
Jan 15, 2005·BMC Psychiatry·Christine LochnerDan J Stein
Jan 15, 2010·Journal of Affective Disorders·Jillian F IkinDean P McKenzie
Jul 25, 2007·International Journal of Psychiatry in Medicine·Scott H Stewart
Jun 1, 2010·Archives of Physical Medicine and Rehabilitation·Rodger A Weddell
Apr 25, 2018·The Cochrane Database of Systematic Reviews·Roberta AgabioPier Paolo Pani
Jan 21, 2015·The Cochrane Database of Systematic Reviews·Jonathan C IpserDan J Stein
May 14, 2010·Neuroscience and Behavioral Physiology·O I MalashenkoA V Pogosov
Mar 22, 2007·Alcoholism, Clinical and Experimental Research·Quyen Q Tiet, Brent Mausbach
Sep 1, 2020·Reviews in the Neurosciences·Milen L RadellAhmed A Moustafa
Nov 30, 2019·Journal of Affective Disorders·Márcio Souto de Castro LongoEvandro Silva Freire Coutinho

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