Does concomitant stress incontinence alter the efficacy of tolterodine in patients with overactive bladder?

The Journal of Urology
Martin C MichelMark Goepel

Abstract

Muscarinic antagonists such as tolterodine are the treatment of choice for overactive bladder (OAB). We determined the impact of concomitant stress incontinence (SI) on the therapeutic effects of tolterodine in patients with OAB with and without concomitant SI. Data from an open label, observational study involving 2,250 patients with OAB symptoms were analyzed for baseline frequency, urgency and incontinence, and alterations in these symptoms while on 12-week treatment with 2 mg tolterodine twice daily. Data are shown as the mean +/- SD. The statistical significance of differences in treatment effects was determined by multiple regression analysis, adjusting for gender, age and baseline symptom intensity. Concomitant I to III degree SI according to the Stamey grading was present in 31%, 15% and 2% of patients, respectively, and it was associated with increasing basal incontinence, although only III degree SI was associated with greater baseline frequency or urgency. In the overall group tolterodine decreased frequency, urgency and urge incontinence from 12.4 +/- 4.3 to 7.7 +/- 2.7, 8.4 +/- 5.1 to 2.0 +/- 3.0 and 3.4 +/- 4.2 to 0.8 +/- 2.0 episodes daily, respectively. On multiple linear regression analysis I and II degree SI h...Continue Reading

References

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Jul 12, 2001·BJU International·J J Wyndaele
Aug 16, 2002·European Urology·Mark GoepelMartin C Michel
Sep 23, 2003·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·V A MinassianA Al-Badr
Sep 23, 2003·The Journal of Urology·Roger R DmochowskiUNKNOWN Duloxetine Urinary Incontinence Study Group

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Citations

Sep 9, 2006·Current Urology Reports·H Henry LaiTimothy B Boone
Apr 21, 2010·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·Ph Ballanger
Oct 8, 2014·Current Urology Reports·Eugene W Lee, Kathleen C Kobashi
Nov 1, 2005·Women's Health·Martin C Michel, Matthias Oelke
Jan 29, 2008·Pharmacology & Therapeutics·Martin C Michel, Maurits M Barendrecht
Aug 9, 2005·BJU International·Martin C Michel, Jean J M C H de la Rosette
May 1, 2010·Neurourology and Urodynamics·Victor W NittiIan W Mills
Sep 25, 2014·Annual Review of Pharmacology and Toxicology·Martin C Michel
Jun 21, 2007·Neurourology and Urodynamics·Alfred E BentRichard C Bump
Oct 6, 2005·Current Opinion in Urology·Roger Dmochowski, David Staskin

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