Does COVID-19 pneumonia signify secondary organizing pneumonia?: A narrative review comparing the similarities between these two distinct entities.

Heart & Lung : the Journal of Critical Care
Woon H ChongAmit Chopra

Abstract

Multiple observational studies have described the similarities between COVID-19 pneumonia and organizing pneumonia (OP). These two entities clinically manifest with mild and subacute respiratory symptoms, often with a delayed diagnosis due to the atypical ARDS and silent hypoxemia presentation. Radiological features are often indistinguishable between the two. With the increase in antemortem lung biopsies and autopsies being performed, more histopathological findings of OP and its variant, acute fibrinous and organizing pneumonia (AFOP), are being diagnosed. These entities are known complications of viral infections as a delayed immunological process, explaining the favorable response to corticosteroids. Clinicians should be vigilant to diagnose this under-recognized entity of secondary OP in people with COVID-19 when clinical deterioration occurs, especially with compatible radiologic findings and recent cessation of corticosteroids. Despite the proven benefits of corticosteroids in treating COVID-19, treatment approaches can be more effective as OP often requires higher doses and a more prolonged therapy duration for remission and preventing relapses. The purpose of our narrative review is to compare the similarities between ...Continue Reading

References

Sep 3, 2002·Archives of Pathology & Laboratory Medicine·Mary Beth BeasleyWilliam D Travis
Apr 22, 2003·AJR. American Journal of Roentgenology·Sang Jin KimKi Jun Sung
Jul 24, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·David M HwangJagdish Butany
Aug 2, 2006·The European Respiratory Journal·J-F Cordier
Sep 23, 2010·AJR. American Journal of Roentgenology·Ju Won LeeMyung Jin Chung
Sep 25, 2012·Seminars in Respiratory and Critical Care Medicine·Vincent Cottin, Jean-François Cordier
Jun 12, 2014·AJR. American Journal of Roentgenology·Amr M AjlanTariq A Madani
Nov 22, 2017·American Journal of Respiratory and Critical Care Medicine·Yaseen M ArabiUNKNOWN Saudi Critical Care Trial Group
Dec 6, 2019·Medicine·Kaige WangDeyun Cheng
Feb 28, 2020·The Lancet Infectious Diseases·Heshui ShiChuansheng Zheng
Feb 29, 2020·The New England Journal of Medicine·Wei-Jie GuanUNKNOWN China Medical Treatment Expert Group for Covid-19
Mar 13, 2020·Annals of Internal Medicine·Huilan ZhangRonghui Du
Apr 1, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Xiaoyu HanHeshui Shi
Apr 14, 2020·The Journal of Infection·Qing YeJianhua Mao
Apr 16, 2020·Intensive Care Medicine·Luciano GattinoniLuigi Camporota
Apr 24, 2020·European Journal of Radiology·Xun DingQingyun Long
Apr 25, 2020·Intensive Care Medicine·Marie-Christine CopinUNKNOWN Lille COVID-19 ICU and Anatomopathology Group
May 2, 2020·Virchows Archiv : an International Journal of Pathology·Angelina PernazzaGiulia d'Amati
May 8, 2020·Critical Care : the Official Journal of the Critical Care Forum·Xu Li, Xiaochun Ma
Jun 17, 2020·American Journal of Respiratory and Critical Care Medicine·Martin J TobinAmal Jubran
Jul 2, 2020·American Journal of Respiratory and Critical Care Medicine·Brian P PogatchnikH Henry Guo
Aug 20, 2020·American Journal of Respiratory and Critical Care Medicine·Vincent JounieauxYazine Mahjoub
Aug 22, 2020·Archives of Pathology & Laboratory Medicine·Anja C RodenJennifer M Boland
Aug 28, 2020·Clinical Imaging·Thomas A McLarenDaniel B Green
Sep 3, 2020·American Journal of Clinical Pathology·Simona De MicheleAnjali Saqi
Sep 3, 2020·JAMA : the Journal of the American Medical Association·UNKNOWN WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working GroupJohn C Marshall

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.