PMID: 8585091Sep 1, 1995Paper

Does crude venom of the stonefish (Synanceia verrucosa) activate beta-adrenoceptors in the frog heart muscle?

Toxicon : Official Journal of the International Society on Toxinology
M P SauviatC Perrière

Abstract

Venom isolated from the stonefish Synanceia verrucosa was assayed in concentrations of 0.07 and 5.7 micrograms/ml on frog atrial fibres and myocytes. Venom, less than 2.9 micrograms/ml, dose-dependently increased the amplitude and the duration of the stimulated peak tension, lengthened the time constant of the relaxation phase and shortened the duration of the action potential (AP). The concentration of venom 5.7 micrograms/ml decreased the amplitude of the peak tension, induced a contracture, reduced the amplitude of the plateau and shortened its duration as well as the repolarizing phase of the AP. The positive inotropic effect induced by the venom (2.9 micrograms/ml) on the contraction was inhibited dose-dependently by propranolol but was unchanged by the alpha-adrenergic antagonists urapidil and yohimbine, the adenyl cyclase activity remaining sensitive to forskolin. Venom, adrenalin and propranolol competed for a common site. Venom (2.9 micrograms/ml) increased both the Ca and the delayed outward K currents of enzymatically isolated atrial myocytes. The data suggest that the venom activates adrenoceptors, essentially beta-adrenoceptors.

References

Apr 30, 1979·Pflügers Archiv : European journal of physiology·M J RouletR Ventura-Clapier
Jan 1, 1969·Pflügers Archiv : European journal of physiology·G VassortY M Gargouïl
Feb 1, 1995·Toxicon : Official Journal of the International Society on Toxinology·P GarnierC Perrière
Jan 30, 1959·Science·P R SAUNDERS

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Citations

Aug 8, 2002·Toxicon : Official Journal of the International Society on Toxinology·Jarrod E Church, Wayne C Hodgson
Jan 1, 1997·Toxicon : Official Journal of the International Society on Toxinology·P GarnierC Perriere
Feb 11, 2000·Toxicon : Official Journal of the International Society on Toxinology·J E Church, W C Hodgson
Mar 23, 2000·Toxicon : Official Journal of the International Society on Toxinology·M P SauviatJ Molgó
Oct 25, 1996·Journal of Chromatography. B, Biomedical Applications·P GarnierC Perrière
May 6, 2015·Toxins·Rebekah Ziegman, Paul Alewood
Nov 3, 2009·Toxicon : Official Journal of the International Society on Toxinology·Helena L GomesMargareth R Moysés
Mar 17, 2007·European Journal of Pharmacology·Jian-Wu WangMasaki Kameyama

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